Science
Mechanism of Action
Palmitoyl Heptapeptide-18 functions as a smart ligand, adeptly identifying neuronal cells that regulate deeper muscle micro-contractions within the skin. Its mechanism involves repressing calcium entry into these neurons, consequently inhibiting the release of acetylcholine into the synaptic space. This interruption of the neuromuscular connection delivers a distinct 'Botox-like effect,' leading to a visible reduction in the appearance of expression lines.
Research
Clinical Evidence
Medium confidence0.001%
Key findings
- 01 When formulated at 0.001% and combined with Palmitoyl Hexapeptide-52, a clinical study involving X50 Myocept and 30 volunteers demonstrated a significant reduction in deep wrinkles and fine lines by 20% to 27% over a 28-day period.
Transparency
Dusting Analysis
No data available regarding 'dusting' or minimal effective concentrations that might indicate dusting concerns for this ingredient.
The Formula
Formulation
Stability
Palmitoyl Heptapeptide-18 benefits from a lipid-modified structure, which enhances its stability, dispersibility, and compatibility within multi-phase systems. However, as with peptides generally, it is susceptible to degradation by enzymes like proteases and can be influenced by various environmental factors or other ingredient incompatibilities.
Synergies
- Palmitoyl Hexapeptide-52
Safety
Safety Profile
There are no specific safety assessments from major regulatory bodies such as CIR, SCCS, or FDA available for Heptapeptide-18 or Palmitoyl Heptapeptide-18 in the provided research data.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Heptapeptide-18 is a valuable ingredient, offering a precision-targeted, 'Botox-like' mechanism to effectively reduce the appearance of expression lines and deep wrinkles, especially when synergistically combined with complementary peptides.
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