Science
Mechanism of Action
Heliopsis Longipes Root Powder, primarily through its key compound affinin, acts via several precise mechanisms on the skin. It functions as an anti-inflammatory agent by inhibiting pro-inflammatory cytokines, such as TNFα, and mitigating free radicals like nitric oxide. Its analgesic and anesthetic properties work directly on pain receptors, reducing sensations of pain and creating a numbing effect. The ingredient also exhibits broad antimicrobial, antibiotic, antifungal, and antiseptic actions by inhibiting the growth of various pathogenic bacteria (e.g., *Streptococcus mutans*, *Escherichia coli*) and fungi. Crucially, it demonstrates a proangiogenic effect, promoting the formation of new blood vessels to enhance wound healing, improve tissue oxygenation, and intensely stimulate local microcirculation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Induced new blood vessel sprouts in ex vivo rat aortic ring assays and demonstrated significant angiogenic effects in in vivo angioreactor assays. Note: A higher concentration of 100 µg/mL showed an inhibitory effect on angiogenesis.
- 02 Inhibited nitric oxide (NO) production in activated murine macrophages, indicating a dose-dependent anti-inflammatory response.
- 03 Displayed analgesic action in mice comparable to the reference drug ketorolac, suggesting effective pain relief.
Transparency
Dusting Analysis
The Formula
Formulation
Conflicts
- Known allergies to plants from the Asteraceae family
Safety
Safety Profile
Toxicological studies in mice indicate safety at recommended doses, with an acute toxicity LD50 of 113 mg/kg, significantly above effective doses. No mutagenic effects were observed by the Ames test, and antimutagenic effects were reported. While considered safe for external use at recommended doses, caution is advised due to its intensity and potential for allergic reactions in individuals sensitive to the Asteraceae family. Not recommended for children under 12 years of age due to intensity, and lacks sufficient research for use during pregnancy or breastfeeding.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Heliopsis Longipes Root Powder is a valuable multi-functional ingredient for precision skincare, offering scientifically supported anti-inflammatory, analgesic, antimicrobial, and proangiogenic benefits for skin repair and comfort, though requiring careful consideration for individuals with Asteraceae allergies or during pregnancy.
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References
Sources