Science
Mechanism of Action
The mechanism of action, predominantly observed in *Helichrysum italicum*, involves anti-inflammatory, antioxidant, and antimicrobial effects that help mitigate acne and inflammatory responses. It promotes skin cell turnover and aids healing by upregulating FGF-2 and HAS-2 gene expressions, crucial for collagen and elastin production, skin repair, and maintaining firmness. Furthermore, its compounds scavenge free radicals, inhibit oxidases, and are thought to enhance microcirculation, offering comprehensive protection against oxidative stress and environmental damage.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 An in-vitro study applying a 5% Helichrysum italicum hydro-alcoholic extract to human dermal fibroblast cells demonstrated significant upregulation of FGF-2 and HAS-2 gene expressions. This indicates anabolic effects on the extracellular matrix, promoting improved wound healing and UV protection. Concentrations exceeding 5% were found to be cytotoxic in this context.
- 02 Another in-vitro study revealed that Helichrysum italicum essential oil at 0.1% and 1% concentrations effectively prevented squalene oxidation when exposed to ozone and singlet oxygen. This highlights its robust antioxidant capabilities and protective action against pollution and UV-induced oxidative stress.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The solubility of Helichrysum components varies, with essential oil forms being lipid-soluble and hydrosols or water-glycerin extracts being water-soluble. No specific optimal pH range for stability in cosmetic formulations was identified. Essential oil forms require dilution with a carrier oil for topical application, and a sensitivity test is advisable prior to use.
Safety
Safety Profile
Specific CIR or SCCS reports for Helichrysum orientale flower or its extract forms are not readily available in the provided data. However, *Helichrysum italicum* extract is generally recognized as a safe cosmetic ingredient by European Union authorities, recommending adherence to manufacturer's instructions. While a 5% hydro-alcoholic extract of *H. italicum* showed efficacy, higher concentrations were noted to be cytotoxic in an in-vitro study. The concentrated essential oil form carries a potential for allergic reactions and is sometimes contraindicated for external use in pregnant or breastfeeding individuals, children, or those on anticoagulant treatment. Dilution and patch testing are recommended.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Helichrysum orientale flower offers valuable multi-functional benefits for skin health, leveraging its strong antioxidant, anti-inflammatory, and reparative properties, largely supported by robust in-vitro research on the closely related *Helichrysum italicum*.
Related
Similar Ingredients
Finding similar ingredients…