Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

HELICHRYSUM ODORATISSIMUM LEAF/STEM EXTRACT.

Valuable / ANTIOXIDANT

Helichrysum Odoratissimum Leaf/Stem Extract is a multi-functional botanical ingredient recognized for its potent anti-inflammatory, antioxidant, and antimicrobial properties. It actively supports skin health by addressing concerns such as acne, oxidative stress, and irritation, while also contributing to scar prevention and photoprotection.

Summary

Antioxidant Anti-inflammatory Antimicrobial Soothing Acne Treatment Scar Prevention Wound Healing SPF Booster

Science

Mechanism of Action

This extract exerts its benefits through a multifaceted action on the skin. It significantly mitigates inflammation by reducing the release of inflammatory cells and decreasing pro-inflammatory cytokine levels, such as IL-1α. Its antimicrobial action controls the proliferation of Cutibacterium acnes, a key bacterium in acne development, and inhibits lipase enzyme activity, which is implicated in sebum degradation and subsequent inflammation. Furthermore, its high radical scavenging activity protects the skin from environmental oxidative damage, and its ability to inhibit hyaluronidase enzyme activity helps to prevent scar formation and supports skin cell turnover and healing.

Research

Clinical Evidence

High confidence
Effective range 5.13–157.5%
Optimal

N/A

Key findings

  1. 01 Exhibited high radical scavenging activity (IC50) at 5.13±0.07 µg/ml, protecting skin from oxidative stress.
  2. 02 Demonstrated a minimum inhibitory concentration (MIC) of 7.81 µg/ml against Cutibacterium acnes, reducing acne pathogenesis.
  3. 03 Reduced interleukin-1α (IL-1α) cytokine levels by 11.08% in C. acnes-induced human keratinocytes.
  4. 04 Showed a 50% inhibitory concentration (IC50) of 157.50 µg/ml against lipase enzyme, reducing sebum-related inflammation.
  5. 05 Exhibited a 50% inhibitory concentration (IC50) of 145.45 µg/ml against virulent hyaluronidase, preventing hyaluronan degradation and scar formation.
  6. 06 Contributed to photostability and maintained SPF values (e.g., 15.8-16.1) in sunscreen formulations, without specified concentration.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 6
0 7 14

Stability

Formulations containing this extract have demonstrated stability under both normal and extreme conditions. The extract itself also contributes to the overall photostability of formulations.

Synergies

  • SPF boosting in sunscreen formulations

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

There are no official safety assessments from regulatory bodies such as CIR, SCCS, or FDA for Helichrysum Odoratissimum Leaf/Stem Extract. However, a commercial supplier indicates it as 'Non-irritant'. In vitro studies suggest that high concentrations were required to achieve significant antiproliferative effects on non-cancerous cells, and no mutagenic or antimutagenic potential has been reported.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Helichrysum Odoratissimum Leaf/Stem Extract is a valuable, multifaceted botanical ingredient for precision skincare, offering robust anti-inflammatory, antimicrobial, and antioxidant benefits for acne-prone, sensitive, and compromised skin, despite the absence of formal regulatory safety reviews.

Related

Similar Ingredients

Finding similar ingredients…