Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

HELICHRYSUM ITALICUM ROOT EXTRACT.

Valuable / SKIN CONDITIONING

Helichrysum Italicum Root Extract is a botanical active recognized for its comprehensive dermatological benefits, including potent anti-inflammatory, antimicrobial, and antioxidant properties. It actively contributes to soothing irritated skin, defending against environmental damage, and enhancing overall skin texture, promoting a revitalized complexion.

Summary

Anti-inflammatory Antimicrobial Antioxidant Skin conditioning Anti-aging Wound healing support Hyaluronic acid synthesis booster

Science

Mechanism of Action

This extract exerts its effects through several biological pathways. It delivers anti-inflammatory actions to calm skin, provides antimicrobial activity against certain pathogens, and functions as an antioxidant to neutralize detrimental free radicals. In vitro research indicates its capacity to support the extracellular matrix (ECM) through anabolic effects, notably upregulating FGF-2 gene expression by 1.74 fold and HAS-2 gene expression by 3.10 fold in dermal fibroblast cell cultures. This suggests an increase in hyaluronic acid synthesis, which can bolster skin hydration, aid in wound healing, and offer anti-aging benefits by potentially influencing collagenase and elastase activity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A diethyl ether extract of Helichrysum italicum demonstrated effectiveness against Herpes Simplex Virus type 1 (HSV-1) in vitro at concentrations ranging from 100-400 µg/mL.
  2. 02 At sub-MIC concentrations of 62.5-125 µg/mL, a diethyl ether extract of Helichrysum italicum reduced the activity of key Staphylococcus aureus enzymes (DNAse, lipase, thermonuclease, coagulase) and inhibited the production of enterotoxins B and C in vitro.
  3. 03 A hydro-alcoholic extract of Helichrysum italicum significantly upregulated FGF-2 gene expression by 1.74 fold and HAS-2 gene expression by 3.10 fold in dermal fibroblast cell cultures, suggesting anabolic effects on the skin's extracellular matrix relevant for anti-aging and wound healing.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

Generally deemed safe for topical application. However, due to potential for individual skin irritation or allergic reactions, a patch test is advised before widespread use. Avoid application on broken or damaged skin. Individuals who are pregnant or breastfeeding should consult a healthcare professional prior to use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Low

Our Assessment

Verdict

Valuable

Helichrysum Italicum Root Extract is a valuable ingredient, showcasing diverse in vitro benefits from anti-inflammatory and antimicrobial actions to significant extracellular matrix support for anti-aging and wound healing, making it a promising addition to precision skincare.

Related

Similar Ingredients

Finding similar ingredients…