HELICHRYSUM ITALICUM PHYTOPLACENTA EXTRACT.

This extract operates via multi-faceted mechanisms to enhance skin health. Its robust antioxidative capacity, attributed to polyphenolic compounds including flavonoids and arzanol, involves scavenging free radicals, inhibiting oxidases, and preventing reactive oxygen species (ROS) formation, thereby offering photoprotection. In an in-vitro model, it demonstrated anabolic effects on the extracellular matrix by upregulating FGF-2 gene expression by 1.74-fold and HAS-2 gene expression by 3.10-fold, critical for anti-aging and tissue repair. Furthermore, key component arzanol exhibits potent anti-inflammatory properties by inhibiting the release of pro-inflammatory interleukins (IL-1β, IL-6, IL-8) and TNFα, and suppressing 5-lipoxygenase and COX-derived prostaglandin E2 biosynthesis. It also stimulates collagen production during tissue regeneration, activates stemness in skin stem cells, and inhibits enzymes such as elastase and collagenase that degrade skin structure.