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Moumoujus

HELICHRYSUM ITALICUM FLOWER EXTRACT.

Valuable CAS 90045-56-0 / PERFUMING

Helichrysum Italicum Flower Extract is a botanical active renowned for its potent anti-inflammatory, antimicrobial, and antioxidant properties. It actively supports skin regeneration and extracellular matrix integrity, offering significant anti-aging and wound healing potential.

Summary

Antioxidant Soothing Moisturizer/Humectant Wound healing Anti-inflammatory Antimicrobial Skin Regeneration Collagen Synthesis Stimulant Photoprotection

Science

Mechanism of Action

This extract operates through a multifaceted mechanism, primarily attributed to its non-volatile polyphenolic compounds, flavonoids, and terpenes. It soothes and calms irritated skin, provides antimicrobial defense, and acts as an antioxidant, protecting against free radical and environmental damage. Crucially, it upregulates FGF-2 (Fibroblast Growth Factor-2) and HAS-2 (Hyaluronan Synthase-2) gene expressions in dermal fibroblast cells, indicating anabolic effects on the skin's extracellular matrix, thereby promoting wound healing and anti-aging. The neryl acetate component further stimulates collagen synthesis, vital for maintaining skin firmness and tone, while its phenol compounds contribute to photoprotection.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

5%

Key findings

  1. 01 An in-vitro study demonstrated that a 5% hydro-alcoholic Helichrysum italicum flower extract significantly upregulated FGF-2 and HAS-2 gene expressions in dermal fibroblast cells, suggesting anabolic effects on the skin's extracellular matrix, crucial for anti-aging and wound healing. Concentrations exceeding 5% were observed to be cytotoxic.
  2. 02 A diethyl ether extract from Helichrysum italicum flowering tops showed effectiveness against herpes simplex virus (HSV-1) at concentrations between 100-400 μg/mL, with flavonoids identified as key active compounds.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Helichrysum extracts should be stored in a cool, dark, and dry place to maintain stability. Its biological activity is highly dependent on its chemical composition, which can vary based on geographical origin, environmental factors, growth phase, and genotype, necessitating careful sourcing and quality control.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) has not formally assessed Helichrysum Italicum Flower Extract. However, regulatory bodies in the European Union generally recognize it as safe for cosmetic use. A patch test is advisable, as some individuals, particularly those sensitive to plants or essential oils, may experience skin irritation or allergic reactions. While contraindications for the *essential oil* exist for pregnant/breastfeeding women, children, and those on anticoagulant treatment, these do not necessarily apply to the flower extract; however, specific safety data for the extract during pregnancy is limited, suggesting cautious use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Helichrysum Italicum Flower Extract offers multifaceted benefits for skin health, including promoting collagen synthesis and wound healing, while providing antioxidant and soothing properties based on in-vitro evidence.

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