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Moumoujus

HEDYSARUM ALHAGI LEAF/STEM EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Derived from the Hedysarum Alhagi plant, this extract is a multi-functional botanical ingredient prized for its potent antioxidant, anti-inflammatory, and antimicrobial properties. It actively protects skin cells from oxidative stress and reduces inflammation, contributing to overall skin health and resilience across various skin types.

Summary

Antioxidant Anti-inflammatory Antimicrobial Skin conditioning Cell protection

Science

Mechanism of Action

HEDYSARUM ALHAGI LEAF/STEM EXTRACT exerts its beneficial effects primarily through its rich content of flavonoids and phenolic compounds. It functions as a powerful antioxidant by effectively neutralizing free radicals, specifically reducing DPPH radicals and superoxide anions. Furthermore, it demonstrates anti-inflammatory action through the inhibition of COX-2 activity, a key enzyme involved in inflammatory pathways. Its broad-spectrum antimicrobial activity against various bacteria and fungi also helps maintain a healthier skin microbiome and environment, while offering protection against cellular oxidative damage.

Research

Clinical Evidence

Medium confidence
Effective range 25–10000%
Optimal

N/A

Key findings

  1. 01 In concentrations of 25 µg/mL and 50 µg/mL, Alhagi graecorum extract protected BV2 and HepG2 cell lines from t-BHP induced oxidative stress and neuroinflammation without exhibiting cytotoxicity.
  2. 02 At 100 µg/mL, Alhagi graecorum extract exhibited significant antioxidant activities by reducing DPPH radicals and superoxide anions, and demonstrated anti-inflammatory properties through COX-2 inhibition in vitro.
  3. 03 An extract of Alhagi maurorum showed substantial antioxidant activity, reaching 93.1±3.46% at a concentration of 100 µg/mL, and effectively neutralized free radicals across a concentration range of 2-10 mg/ml.
  4. 04 Antimicrobial properties were identified for Alhagi maurorum leaf and flower extracts, with minimum inhibitory concentrations for antibacterial and antifungal activity ranging from 58.0-84.0 µg/ml against various microorganisms.

Transparency

Dusting Analysis

Not commonly dusted

Insufficient data available to assess dusting potential or common practice for this ingredient.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Specific optimal pH range and detailed stability notes were not identified in the available research.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments by CIR, SCCS, or FDA for topical use were found. While Alhagi species are generally considered to have low toxicity, caution regarding potential DNA damage from ingestion of a related species (A. pseudalhagi) at specific concentrations has been noted. It is recognized in cosmetics for its skin conditioning properties.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

HEDYSARUM ALHAGI LEAF/STEM EXTRACT is a valuable botanical ingredient, demonstrating robust antioxidant, anti-inflammatory, and antimicrobial benefits across a wide range of concentrations in in-vitro and cell-line studies, making it suitable for diverse skin types.

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