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Moumoujus

HARPAGOPHYTUM PROCUMBENS ROOT EXTRACT.

Valuable CAS 84988-65-8 / SKIN CONDITIONING

Harpagophytum Procumbens Root Extract, commonly known as Devil's Claw, delivers potent anti-inflammatory and soothing benefits to the skin. It effectively diminishes redness, irritation, and swelling, while also supporting skin regeneration and reinforcing the epidermal barrier through reduced transepidermal water loss.

Summary

skin conditioning Anti-inflammatory Soothing Anti-redness Skin regeneration Barrier support

Science

Mechanism of Action

This extract mediates its anti-inflammatory effects primarily through a rich composition of iridoid glycosides, notably harpagoside and harpagide. Its mechanism involves CB2 activation, interference with the AP-1 pathway, and suppression of NF-κB, which collectively inhibit inflammatory processes. This action significantly reduces the release of key pro-inflammatory mediators such as TNF-α, interleukin 6 (IL-6), and PGE2, and downregulates the expression of inflammatory genes including COX-2.

Research

Clinical Evidence

Medium confidence
Effective range 50–200%
Optimal

5%

Key findings

  1. 01 In vitro studies demonstrate a dose-dependent reduction in COX-2 mRNA quantity, with effects observed from 50 μg/mL up to 200 μg/mL.
  2. 02 In vitro research indicates suppression of TNF-α and interleukin 6 (IL-6) at concentrations of 100 μg/mL and 200 μg/mL.
  3. 03 The cosmetic industry commonly recommends application concentrations up to 5%.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.1%

With cosmetic industry recommendations suggesting application concentrations up to 5%, Harpagophytum Procumbens Root Extract is intended for functional inclusion at levels significantly above typical dusting thresholds. This indicates that formulators aim for demonstrable biological activity, making 'dusting' highly improbable for this ingredient.

The Formula

Formulation

Solubility
Water
Optimal pH 3.9 – 7.2
0 7 14

Stability

For optimal stability, store in a dry environment between 10°C and 30°C in its originally sealed container for up to 24 months. Minor color variations may occur during storage, influenced by temperature.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Pregnancy
Caution
Sensitization risk Low

Harpagophytum Procumbens Root Extract is generally considered non-comedogenic and non-toxic for topical use. However, individual patch testing is advised for first-time users. Due to insufficient research, its internal use is not recommended for pregnant or breastfeeding individuals, or for those under 18, with these precautions potentially extending to topical applications in specific contexts. Oral consumption has contraindications for individuals with gastric/duodenal ulcers, gallstones, or cardiovascular disorders due to its bitter substances stimulating stomach acid production and other systemic effects.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Harpagophytum Procumbens Root Extract is a valuable addition to Moumoujus formulations due to its scientifically supported anti-inflammatory and soothing properties, broad skin type compatibility, and established usage within the cosmetic industry.

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