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HAMAMELIS VIRGINIANA LEAF EXTRACT.

Valuable CAS 84696-19-5 / SKIN CONDITIONING

Hamamelis Virginiana Leaf Extract is a multi-functional botanical ingredient renowned for its potent anti-inflammatory, antioxidant, and astringent properties. It actively soothes skin, refines pores, and offers protection against environmental stressors, making it a valuable addition to precision skincare formulations.

Summary

Astringent Antioxidant Anti-inflammatory Soothing Antimicrobial

Science

Mechanism of Action

This extract functions as an anti-inflammatory by inhibiting crucial inflammatory mediators like IL-6, IL-8, IL-17C, and TSLP, primarily through modulating the NF-κB signaling pathway and aiding in skin barrier restoration. Its rich content of galloylated tannins and polyphenols confers powerful antioxidant benefits, neutralizing free radicals and shielding skin cells from oxidative damage. The tannins also contribute to its astringent effect, helping to minimize pore appearance and control excess sebum. Furthermore, it demonstrates antimicrobial efficacy against various bacteria and fungi by disrupting microbial cell structures and preventing biofilm formation, while also protecting keratinocytes from particulate matter-induced damage.

Research

Clinical Evidence

High confidence
Effective range 0.45–2%
Optimal

1.8%

Key findings

  1. 01 Hamamelis Virginiana Extract significantly inhibited the release of multiple inflammatory mediators (IL-6, IL-17C, TSLP, IL-8, CCL26, MMP-9) in a concentration-dependent manner, while also counteracting the proliferative effects of IL-4, suggesting strong anti-inflammatory potential.
  2. 02 Hamamelis Virginiana stem and leaf extract demonstrated anti-pollution effects by successfully inhibiting Ca2+ influx in HaCaT cells induced by fine particulate matter (25 μg/mL). This protective action involves the regulation of PAR-2, NF-κB, and occludin, crucial for barrier function.
  3. 03 The extract showed a significant reduction in microbial biofilm formation; specifically, over 75% reduction for most Candida species at 100 mg/mL within 5 minutes, and over 79% reduction for Candida species, E. coli, and K. pneumoniae at 12.5 mg/mL over 24 hours.

Transparency

Dusting Analysis

Not commonly dusted

As an active botanical extract, Hamamelis Virginiana Leaf Extract is typically incorporated for its functional benefits rather than used as an inert filler.

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 5
0 7 14

Stability

Optimal stability for this ingredient is observed within an acidic pH range.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
50%
Sensitization risk Moderate

The CIR Expert Panel concluded that Hamamelis virginiana-derived ingredients are safe in cosmetics when formulated to be non-irritating and non-sensitizing. While Hamamelis Virginiana Leaf Extract specifically has been found non-irritating and non-sensitizing at up to 0.45% in HRIPTs, the highest reported leave-on cosmetic concentration for general Hamamelis Virginiana Extract is 1.8%. Higher concentrations, such as those permitted by the FDA for OTC drug products (10% to 50%), may potentially cause skin irritation, dryness, or sensitization due to its high tannin content if used repeatedly or improperly formulated.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Medium
Comedogenicity Low

Our Assessment

Verdict

Valuable

Hamamelis Virginiana Leaf Extract is a valuable ingredient for targeting inflammation, oxidative stress, excess oil, and environmental damage, offering comprehensive benefits for a range of skin concerns.

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