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Moumoujus

HAEMATOXYLUM CAMPECHIANUM WOOD EXTRACT.

Insufficient Data CAS 8005-33-2 / COLORANT

HAEMATOXYLUM CAMPECHIANUM WOOD EXTRACT is derived from the logwood tree, recognized for its rich natural pigment and diverse phytochemical composition. This extract demonstrates potential anti-inflammatory and antioxidant capabilities, alongside a notable capacity to reduce melanin production for skin brightening, largely attributed to its primary active component, haematoxylin.

Summary

Colorant Antioxidant Anti-inflammatory Skin Brightening Astringent

Science

Mechanism of Action

The efficacy of HAEMATOXYLUM CAMPECHIANUM WOOD EXTRACT is driven by a complex profile of constituents, prominently featuring haematoxylin—a neoflavonoid—in synergy with gallotannins, flavonoids, flavonols, and chalcones. At a biochemical level, it functions as an antioxidant by ameliorating oxidative stress markers. Its anti-inflammatory action involves targeting key pathways such as COX, LOX, and PGE, and it can also inhibit protein tyrosine kinase activity. Specifically, haematoxylin has been observed to decrease melanin synthesis, thereby promoting a skin whitening effect. The extract also possesses mild astringent qualities.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Research indicates that haematoxylin, a primary component of the wood extract, effectively reduces melanin production, contributing to a skin whitening effect.
  2. 02 Systemic animal studies, utilizing a flower extract form, have demonstrated notable peripheral and central analgesic and anti-inflammatory effects, ameliorating oxidative stress and inflammatory markers. A 600 mg/kg dose resulted in a 45% reduction in edema thickness in a rat model.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extract functions as a pH indicator, displaying a yellowish-red hue under acidic conditions, appearing brownish when neutral, and turning purple in alkaline environments. Its intrinsic color stability is moderate to light, though it can be enhanced through the incorporation of iron.

Synergies

  • Iron (for improved color stability)

Conflicts

  • pH variations (significantly alter the extract's color, affecting product aesthetics)
  • Certain metal mordants (e.g., iron, alum, copper) which are known to drastically change its resultant color in formulations

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

HAEMATOXYLUM CAMPECHIANUM WOOD EXTRACT is recognized by the FDA as a color additive under the designation 'Logwood extract.' While not reviewed by CIR, a Safety Data Sheet indicates no known sensitizing effects, mutagenicity, reproductive toxicity, or carcinogenicity for Logwood Extract powder. However, it is explicitly not recommended for fragrance or flavor applications.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

HAEMATOXYLUM CAMPECHIANUM WOOD EXTRACT demonstrates promising mechanisms as an antioxidant, anti-inflammatory, and skin brightening agent; however, specific human topical efficacy studies and optimal concentrations for skincare applications are currently insufficient to warrant a higher rating.

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