Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

GYNURA PROCUMBENS LEAF EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Gynura Procumbens Leaf Extract is a botanical active renowned for its multifaceted dermatological benefits, including potent antioxidant and anti-inflammatory properties. It actively promotes skin regeneration and wound healing by stimulating crucial growth factors, supporting a robust and resilient skin barrier.

Summary

Antioxidant Anti-inflammatory Wound Healing Melanin Production Enhancement Collagen Protection (MMP Inhibition) Skin Regeneration Moisturizing Antibacterial Antiviral Anti-dermatitis Anti-wrinkle Skin Temperature Regulation

Science

Mechanism of Action

This extract operates through several key mechanisms to enhance skin health. It exhibits significant free radical scavenging activity, functioning as a powerful antioxidant to protect skin cells from oxidative stress. It accelerates wound healing and neovascularization by inducing the expression of vital growth factors such as angiogenin, epidermal growth factor, fibroblast growth factor, transforming growth factor-beta, and vascular endothelial growth factor. The extract also enhances the migration and proliferation of endothelial cells, fibroblasts, keratinocytes, and mast cells, all crucial for tissue repair. Additionally, it demonstrates anti-inflammatory effects via compounds like kaempferol and other flavonoids, inhibits UV-B-induced matrix metalloproteinases, and can increase melanin production. It may also modulate immune responses and help regulate skin temperature for optimal skin conditions.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical application of an oil extract demonstrated an average success rate of 83.8% in treating onychomycosis, with no reported side effects.
  2. 02 In a study of 8 volunteers with vitiligo, twice-daily topical application of the oil extract combined with 30 minutes of daily sunlight achieved over 80% treatment success.
  3. 03 Topical application of the extract on diabetic mice significantly accelerated wound healing, promoting neovascularization and inducing the expression of multiple growth factors.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Specific optimal pH for stability has not been identified. To enhance dispersibility and solubility, especially in aqueous and gastric-like fluids, the use of advanced delivery systems such as Self-Microemulsifying Drug Delivery Systems (SMEDDS) and nanoliposomal systems is indicated.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Gynura Procumbens leaves are generally considered non-toxic. Topical applications of its oil extract in clinical studies for onychomycosis and vitiligo reported no adverse side effects. While in vitro studies on macrophages showed weak cytotoxicity at specific concentrations, comprehensive, dose-dependent safety evaluations are necessary for cosmetic applications. Formal safety assessments by regulatory bodies like CIR, SCCS, or FDA are currently unavailable.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Gynura Procumbens Leaf Extract offers valuable multi-functional benefits for skin health, particularly in anti-inflammatory and regenerative processes, warranting further exploration despite a current lack of specified optimal cosmetic concentrations.

Related

Similar Ingredients

Finding similar ingredients…