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Moumoujus

GYMNEMA SYLVESTRE STEM EXTRACT.

Valuable CAS 90045-47-9 / HUMECTANT

Gymnema Sylvestre Stem Extract is a potent botanical active that supports fundamental cellular energy processes, contributing to overall skin revitalization and a more youthful appearance. It significantly promotes collagen synthesis, enhances moisture retention, and offers natural brightening benefits, establishing itself as a multifaceted ingredient for comprehensive skin health.

Summary

antioxidant skin-conditioning anti-aging brightening moisturizing skin energizing wound healing support anti-inflammatory antimicrobial

Science

Mechanism of Action

This extract primarily functions by activating critical metabolic pathways within skin cells. It demonstrably increases adenosine triphosphate (ATP) synthesis, stimulates cytochrome c oxidase activity, and induces ribose 5-phosphate synthesis in both human keratinocytes and fibroblasts. These actions are vital for optimizing cellular energy production and regulating skin metabolic processes. Additionally, the extract directly stimulates collagen synthesis, which improves skin firmness and elasticity. It exhibits antioxidant and anti-inflammatory properties by modulating inflammatory responses, including reducing pro-inflammatory cytokines and increasing anti-inflammatory cytokines. Its influence on melanin formation contributes to skin brightening, complemented by its antimicrobial effects.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–10%
Optimal

N/A

Key findings

  1. 01 At concentrations ranging from 0.01% to 10%, studies show increased synthesis of ATP, stimulated activity of cytochrome c oxidase, and induced synthesis of ribose 5-phosphate in human keratinocytes and fibroblasts, crucial for regulating skin's metabolic and energy processes.
  2. 02 It stimulates collagen synthesis, actively promoting skin firmness and elasticity, which visibly lessens the appearance of wrinkles, fine lines, and sagging skin.
  3. 03 The extract enhances the skin's capacity for moisture retention, supporting a youthful complexion, maintaining skin suppleness, and effectively soothing dryness.
  4. 04 It possesses natural skin-brightening properties, aiding in the evenness of skin complexion and reducing the visibility of age spots, sun spots, and blemishes by impacting melanin formation.
  5. 05 Research indicates its potential in wound healing by promoting cellular attachment, spreading, and proliferation of human primary dermal fibroblasts and cultured keratinocytes.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Low

Specific topical cosmetic safety assessments by regulatory bodies such as CIR, SCCS, or FDA are currently not available. Oral toxicity studies generally classify Gymnema sylvestre extract as non-toxic, with an LD50 greater than 5000 mg/kg BW in acute oral rat tests. However, sub-acute oral doses of 300-600 mg/kg BW have been linked to potential liver and kidney compromise in rats, suggesting an oral dose of 100 mg/kg or below for safety. Due to a lack of reliable information, topical use during pregnancy and breastfeeding is not advised.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Gymnema Sylvestre Stem Extract is a valuable ingredient for revitalizing and maintaining skin health, offering benefits in energy metabolism, collagen support, hydration, and brightening, with low irritation potential across all skin types.

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