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GUANIDINE PHOSPHATE.

Questionable CAS 5423-22-3 / SKIN CONDITIONING

Guanidine Phosphate is a white, crystalline compound primarily employed in cosmetic formulations as a buffering agent, helping to precisely control and maintain product pH for optimal stability.

pH Adjuster Buffering Agent

Science

This ingredient functions as a buffering agent within cosmetic and personal care formulations. Its role is to stabilize the pH balance, which is crucial for maintaining the integrity, efficacy, and shelf-life of other active ingredients and the overall product formulation.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Guanidine Phosphate is a white crystalline powder exhibiting high solubility in water, dissolving at a rate of 15.5 g per 100 g at 20°C, or 250 g/L. It shows limited solubility in methanol and is practically insoluble in non-polar organic solvents such as benzene, acetone, and diethyl ether. It is primarily used to adjust and stabilize the pH of solutions.

Conflicts

  • strong oxidizing agents

Safety

CIR Status
Not reviewed
Sensitization risk Moderate

Hazard statements for Guanidine Phosphate indicate it can be harmful if swallowed, comes into contact with skin, or is inhaled, and is irritating to both eyes and skin. There is currently no specific safety assessment available from the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS), nor is its status defined by the FDA for cosmetic use.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Questionable

While Guanidine Phosphate serves as an effective pH buffering agent, its classification with hazard statements for skin and eye irritation, coupled with a lack of formal safety review by key regulatory bodies, raises significant concerns for its use in precision skincare.


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