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Moumoujus

GUAIAZULENE.

Valuable CAS 489-84-9 / ANTIMICROBIAL, PERFUMING

Guaiazulene is a naturally derived azulene compound, renowned for its distinct blue hue and multifaceted benefits. This potent ingredient is primarily celebrated for its soothing and anti-inflammatory properties, effectively calming irritated skin.

Summary

Anti-inflammatory Soothing Antioxidant Antimicrobial/Antibacterial Skin Barrier Support Skin Regeneration Fragrance

Science

Mechanism of Action

Guaiazulene exerts its action by significantly reducing inflammation, targeting pro-inflammatory cytokines and enzymes while neutralizing reactive oxygen species (ROS). It acts as a powerful antioxidant, mitigating oxidative stress and free radical damage. Furthermore, it enhances skin barrier function, promotes cellular regeneration, supports moisture retention, and offers beneficial antimicrobial activity.

Research

Clinical Evidence

High confidence
Effective range 0.01–0.1%
Optimal

0.03%

Key findings

  1. 01 Demonstrated efficacy in leave-on cosmetic products for its soothing, anti-inflammatory, and antioxidant benefits.
  2. 02 Proven effective in rinse-off cosmetic formulations, delivering soothing, anti-inflammatory, and antioxidant advantages.
  3. 03 Successfully utilized in calming creams and sun lotions to combat inflammation and redness, proving especially suitable for sensitive and acne-prone skin.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 4 – 6.5
0 7 14

Stability

Guaiazulene is photolabile, degrading when exposed to light, particularly UVA and visible spectrum. Its characteristic blue color is also unstable under acidic conditions. Optimal storage involves cold temperatures, protection from light, and avoidance of temperatures exceeding 40°C.

Conflicts

  • strong oxidizing agents
  • light/UV exposure
  • high heat (above 40°C)

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.1%
Sensitization risk Low

Approved by the FDA as a human-safe colorant for external cosmetics without certification. It is generally well-tolerated, even on hypersensitive skin, and is considered non-irritating. However, prolonged dermal exposure may infrequently trigger mild irritation or allergic contact dermatitis in highly sensitive individuals. The maximum concentration is 0.05% for leave-on products and 0.1% for rinse-off products.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Guaiazulene is a valuable ingredient for precision skincare, offering potent anti-inflammatory, antioxidant, and soothing benefits with broad skin compatibility and low risk of irritation.

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