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Moumoujus

GUAIACUM OFFICINALE WOOD EXTRACT.

Insufficient Data CAS 84650-13-5 / PERFUMING, SKIN CONDITIONING

Guaiacum Officinale Wood Extract is a botanical active revered for its intense moisturizing and potent antioxidant properties. It actively supports the skin's natural barrier, offers deep hydration, and exhibits anti-inflammatory effects to soothe irritated or sensitive skin, while also addressing visible signs of aging.

Summary

Moisturizing Anti-aging Anti-inflammatory Antioxidant Skin Barrier Support Skin Conditioning Perfuming

Science

Mechanism of Action

This extract operates by fortifying the skin's intrinsic barrier, delivering profound hydration, and modulating inflammatory responses, specifically by inhibiting interferon gamma (IFNγ) release. Its rich composition includes guaiacol, lignan resins, and triterpene saponins, which contribute to its antioxidant capabilities and efficacy in mitigating aging indicators.

Research

Clinical Evidence

Medium confidence
Effective range 1–50%
Optimal

2%

Key findings

  1. 01 Demonstrated optimal efficacy in moisturizing and anti-aging formulations, enhancing skin barrier function, providing deep hydration, and calming sensitive or irritated skin.
  2. 02 When formulated at 5 wt% in combination with Rhodomyrtus tomentosa extract, a cream significantly improved facial acne and redness, resulting in a 50% decrease in comedones and a 30.65% reduction in papules over 28 days.
  3. 03 Cited in pharmaceutical compositions for its suitability in treating skin inflammations by inhibiting the release of interferon gamma (IFNγ).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3.9 – 7.2
0 7 14

Stability

The aqueous extract is free of essential oils and maintains stability within the optimal pH range. It is compatible for formulation with pentylene glycol, propylene glycol, glycerin, jojoba seed oil, squalane, and sunflower seed oil. It can also be incorporated as a powder extract utilizing maltodextrin as a carrier.

Synergies

  • Rhodomyrtus tomentosa (for enhanced acne and redness reduction)

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that the available data are insufficient to support the safety of Guaiacum officinale wood extract. Reliable information regarding its safety for topical application and potential side effects, including skin rashes, is limited. While cosmetic products and ingredients in the US do not require FDA pre-market approval, companies are responsible for their safety. The FDA lists Guaiac wood extract as a natural flavoring substance.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Guaiacum Officinale Wood Extract exhibits promising benefits for hydration, anti-aging, and soothing sensitive skin, the Cosmetic Ingredient Review (CIR) Expert Panel has deemed data insufficient to support its safety for cosmetic use.

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