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Moumoujus

GRINDELIA ROBUSTA EXTRACT.

Valuable CAS 84696-17-3 / SKIN CONDITIONING, TONIC

Grindelia Robusta Extract is a botanical ingredient distinguished by its robust anti-inflammatory, antioxidant, and protective capabilities. It efficiently modulates cellular inflammatory pathways and neutralizes oxidative stress, while also actively safeguarding the dermal matrix from enzymatic degradation and environmental aggressors like UV radiation.

Summary

Anti-inflammatory Antioxidant UV Protective MMP Inhibitor Skin Conditioning Tonic Wound Healing Support Skin Cell Regeneration Dermal Matrix Protection

Science

Mechanism of Action

This extract mediates its anti-inflammatory action by dose-dependently inhibiting the secretion of key pro-inflammatory mediators, including IL-6, TNF-α, RANTES, MCP-1, and PGE2. Furthermore, it significantly reduces the activity of multiple matrix metalloproteinases (MMP-1, -3, -7, -8, -9, -13), primarily through the suppression of nuclear factor-kappa B (NF-κB) p65 activation. Its rich composition of flavonoids (e.g., quercetin, kaempferol) and phenolic acids confers potent antioxidant protection against free radical damage. Beyond these, Grindelia robusta extract supports skin cell regeneration and fortifies the dermal elastic network, thereby preserving the skin's biomechanical integrity and resilience.

Research

Clinical Evidence

Medium confidence
Effective range 0.05–0.5%
Optimal

N/A

Key findings

  1. 01 In a macrophage model, concentrations ranging from 25-100 µg/ml dose-dependently inhibited the secretion of inflammatory mediators (IL-6, RANTES, MCP-1, PGE2, TNF-α) and matrix metalloproteinases (MMP-1, -3, -7, -8, -9, -13), associated with reduced NF-κB p65 activation.
  2. 02 At a 0.5% concentration, the extract effectively limited the basal level of reactive thiobarbituric acid species (TBARs) and strongly inhibited UV-induced TBARs, demonstrating significant antioxidant and UV protective activity.
  3. 03 Normal human fibroblast cultures exposed to 0.05%, 0.1%, and 0.2% concentrations exhibited protective activity against UV irradiation.

Transparency

Dusting Analysis

Not commonly dusted

No data available to indicate dusting concerns for Grindelia Robusta Extract in cosmetic applications.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

As a polar extract, Grindelia robusta is soluble in polar solvents, notably water. Hydro-alcoholic solutions (e.g., 45% alcohol) and vegetable palm glycerin are common preparation methods, with water:ethanol extracts demonstrating high phenolic acid content contributing to antioxidant stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not specifically assessed Grindelia Robusta Extract. The EWG Skin Deep database rates it with 'LOW' concern for cancer, allergies & immunotoxicity, developmental and reproductive toxicity, and use restrictions, though noting limited scientific data availability. Studies report using non-cytotoxic concentrations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Grindelia Robusta Extract is a valuable multi-functional ingredient for Moumoujus, offering significant anti-inflammatory, antioxidant, and protective benefits to enhance skin resilience and combat environmental stressors.

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