GRIFOLIA FRONDOSA MYCELIUM FERMENT FILTRATE EXTRACT.

This extract precisely targets and modulates key cellular pathways implicated in inflammation and oxidative stress. It primarily inhibits the MAPK (Mitogen Activated Protein Kinase) signaling pathways, thereby suppressing the production of pro-inflammatory cytokines (such as IL-1β) and chemokines in keratinocytes, which contributes to its ameliorative effects in conditions mimicking atopic dermatitis. Furthermore, it functions as a potent antioxidant by scavenging intracellular Reactive Oxygen Species (ROS) and preventing ERK phosphorylation, offering protection against environmental aggressors like Bisphenol A (BPA). Its mechanism also involves attenuating inflammatory responses and preventing dermal fibroblastic pyroptosis by suppressing the redox-sensitive transcription factor NF-κB and blocking inflammasome-mediated caspase-1 activation. Its efficacy is fortified by bioactive components including naringin, hesperidin, chlorogenic acid, and kaempferol.