Science
Mechanism of Action
The ferment filtrate leverages the distinct biological activities of its individual botanical components. Grifola Frondosa contributes anti-inflammatory properties by inhibiting MAPK signaling pathways and suppressing pro-inflammatory cytokines, which may alleviate symptoms of inflammatory skin conditions. It also demonstrates significant antioxidant activity, helps reduce hyperpigmentation by inhibiting tyrosinase, and supports skin regeneration through promoting wound healing and collagen biosynthesis. Ophioglossum Vulgatum further enhances antioxidant defense by scavenging free radicals and provides additional anti-inflammatory effects by regulating Nrf2/HO-1/COX2 and TLR4/MYD88 signaling pathways. Moreover, it stimulates HaCaT cell proliferation and migration, upregulating collagen type I alpha 1 chain (COL1A1) and fibronectin 1 (FN1) via the PI3K/AKT/GSK3-β pathway, thereby supporting skin structure and repair.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically assessed this combined Grifola Frondosa/Ophioglossum Vulgatum Extract Ferment Filtrate. While some yeast-derived ingredients have been reviewed, explicit safety data for this particular complex is not listed. Toxicity data (oral, parenteral, dermal, inhalation) for similar ferment filtrates are noted as undetermined by The Good Scents Company.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient exhibits promising multi-functional benefits based on the established properties of its individual botanical components, yet comprehensive clinical efficacy and safety data for the combined ferment filtrate are currently not available.
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