GRIFOLA FRONDOSA /LICORICE ROOT EXTRACT FERMENT FILTRATE.

This ingredient functions by integrating the distinct biological activities of its fermented components. Grifola Frondosa works to up-regulate genes critical for essential collagen production, thereby enhancing fibroblast-mediated collagen synthesis, fortifying the extracellular matrix, and improving skin thickness for a smoother, more youthful complexion. It also delivers potent anti-inflammatory action by blocking inflammasome-mediated caspase-1 activation and suppressing NF-κB in dermal fibroblasts, alongside antioxidant defense through inhibition of reactive oxygen species. Furthermore, it can ameliorate atopic dermatitis by suppressing multiple immune responses (Th1, Th2, Th17, Th22) and inflammatory cytokines via MAPK pathway inhibition. Licorice Root contributes significantly to skin brightening by inhibiting tyrosinase activity, notably via its active component glabridin, while also providing substantial anti-inflammatory, hydrating, and antioxidant benefits. The fermentation process optimizes the bioavailability of these active compounds, facilitating enhanced absorption and amplified efficacy across all mentioned pathways.