Science
Mechanism of Action
The extract's broad spectrum of action is rooted in its rich phytochemical composition, which includes betacyanins, various polyphenols (such as kaempferol, quercetin, isorhamnetin, rutin, caffeic acid, gallic acid, and quinic acid), saponins, and triterpenoids. These compounds synergistically scavenge free radicals, chelate metal ions, and inhibit key enzymes like collagenase and elastase, thereby mitigating oxidative damage and supporting skin's structural integrity. Anti-inflammatory effects are primarily mediated by flavonoids, saponins, and terpenes, which suppress nitric oxide production. Its betacyanin content also contributes to antibacterial efficacy, while other constituents provide effective humectant properties, ensuring sustained skin hydration.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated significant antioxidant activity via DPPH radical scavenging for ethanol flower extract, with an IC50 of 49.9 µg/ml.
- 02 Exhibited anti-inflammatory effects by reducing LPS-induced nitric oxide production to basal levels at concentrations between 50-200 µg/ml.
- 03 Showed strong inhibition of collagenase and moderate inhibition of elastase, indicative of anti-aging properties.
- 04 Provided effective and long-lasting hydration to the skin.
- 05 Displayed antibacterial efficacy against Escherichia coli at concentrations ranging from 200-350 µg/µl, with ultrasonic extracts showing greater inhibition.
- 06 Cytotoxicity studies indicated the flower extract was non-toxic at an IC50 of 1700 µg/ml.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Key components, such as betacyanins, maintain stability within a pH range of 3.0 to 7.0. The extract has been successfully incorporated into cosmetic preparations like lip creams, demonstrating good stability over 28 days with an average pH of 6-7. It is also noted for its ability to retain its vibrant color over time, even after drying, and does not significantly alter the color of final cosmetic emulsion products.
Safety
Safety Profile
No specific regulatory reviews from CIR, SCCS, or FDA were identified. However, in vitro cytotoxicity studies consistently indicate a generally non-toxic profile for the extract at concentrations relevant to cosmetic use. Further support for its safety comes from INCI Beauty, which assigns 'No penalty' across all categories for this ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
With its proven multi-functional benefits spanning antioxidant, anti-inflammatory, anti-aging, and hydrating properties, Gomphrena Globosa Flower Extract is a valuable botanical for diverse skincare formulations.
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