Science
Mechanism of Action
This extract primarily functions as a robust antioxidant by directly scavenging a broad spectrum of free radicals, including DPPH, ABTS, superoxide, and hydroxyl radicals, while effectively inhibiting lipid peroxidation. Its anti-inflammatory action involves reducing nitric oxide (NO) levels, downregulating pro-inflammatory cytokines such as TNF-α, IL-1β, and COX-2, and suppressing the NF-κB signaling pathway by decreasing phosphorylated p65 and IκBα. Additionally, it exhibits antibacterial and antifungal activities.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies have demonstrated significant antioxidant capacity, achieving an IC50 of approximately 72.9 ± 3.2 µg/mL for DPPH radical scavenging.
- 02 Further in vitro research confirms its remarkable ability to neutralize ABTS, DPPH, superoxide, and hydroxyl radicals, alongside inhibiting lipid peroxidation. Quercetin has been identified as a main antioxidant component.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not yet reviewed Gnaphalium affine extract, and it has no reported uses under FDA's Voluntary Cosmetics Reporting Program. However, in vitro assessments across normal cell lines (RAW264.7, HEK293, HaCaT) indicate no cytotoxic effects, suggesting a low toxicity profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Gnaphalium affine extract is a valuable multi-functional ingredient due to its potent antioxidant and anti-inflammatory capabilities, making it beneficial for protecting and soothing diverse skin types.
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References
Sources