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Moumoujus

GMELINA ARBOREA ROOT EXTRACT.

Optional CAS 92201-79-1 / SKIN CONDITIONING

Gmelina Arborea Root Extract is recognized for its comprehensive skin conditioning properties, working to maintain the skin's optimal state by enhancing softness, smoothness, and hydration. It functions primarily as a moisturizer, actively preventing dryness and preserving dermal suppleness. This botanical extract also presents promising antioxidant and anti-inflammatory benefits.

Summary

skin conditioning moisturizing antioxidant anti-inflammatory

Science

Mechanism of Action

This root extract operates by leveraging a rich profile of bioactive compounds, including flavonoids, iridoid glycosides, and various other phytochemicals. These constituents collectively contribute to its skin conditioning effect, ensuring the skin remains soft and hydrated. Furthermore, the extract's antioxidant capacity is mediated through the elevation of endogenous antioxidant enzymes, such as superoxide dismutase, catalase, and glutathione reductase, which protect cellular structures from oxidative stress. Its anti-inflammatory action helps to soothe the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Systemic administration of aqueous and methanol extracts (500 mg/kg) in Wistar albino rats demonstrated significant anti-inflammatory effects, inhibiting carrageenan-induced inflammation by up to 30.15% and 31.21% respectively.
  2. 02 In systemic animal models, high doses of the extract exhibited anti-inflammatory effects comparable to aspirin, effectively reducing paw edema and decreasing dry granuloma weight in rats.
  3. 03 Systemic application (200 mg/kg) in animal studies promoted enhanced wound healing, along with improvements in skin breathing strength, granuloma breaking strength, and granuloma weight.
  4. 04 Rats receiving a systemic dose of 150 mg/kg/day demonstrated notable antioxidant effects.
  5. 05 In vitro testing revealed vasodilating effects at concentrations ranging from 0.5-1.5 mg.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally considered safe for topical cosmetic application, with infrequent reports of side effects such as mild skin irritation, allergic reactions, redness, or itching; patch testing is recommended. Acute and repeated dose toxicity studies in rodents indicated safety without significant hematological or biochemical alterations. Specific data regarding topical use during pregnancy and breastfeeding are currently unavailable, necessitating consultation with a healthcare professional for these individuals.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Optional

Gmelina Arborea Root Extract is an optional ingredient offering skin conditioning, moisturizing, and potential protective benefits, although robust human topical clinical efficacy data is currently limited.

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