Science
Mechanism of Action
This sprout extract operates via multiple pathways to enhance skin health. Its antioxidant action effectively neutralizes free radicals, thereby shielding skin from oxidative damage and premature aging. As an anti-inflammatory agent, it leverages active compounds like glycyrrhizin to soothe redness and irritation. Furthermore, it targets hyperpigmentation by inhibiting tyrosinase, a key enzyme in melanin synthesis, leading to reduced dark spots and melasma. The extract also supports skin moisturization, aids in toning, and helps maintain elasticity, with some studies suggesting wound healing properties.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A herbal composition containing 0.1% Glycyrrhiza uralensis root extract and 0.6% glycyrrhizinic acid demonstrated anti-inflammatory effects comparable to 1% hydrocortisone acetate in a placebo-controlled double-blind UV-erythema test study, 48 hours post-irradiation and cream application.
- 02 General licorice extracts at 0.5% and 1.0% exhibited effective natural antioxidant activity within a cream formulation.
- 03 Glabridin, a prominent flavonoid found in Glycyrrhiza, effectively inhibited tyrosinase activity in cultured B16 murine melanoma cells.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Glycyrrhizin, a primary active component, demonstrates high stability under thermal treatments (100-121°C) across a wide pH range of 4.5 to 9.5. Formulations should monitor for potential changes in viscosity over time. The extract also possesses emulsifying properties, which can assist in blending disparate phases.
Safety
Safety Profile
Glycyrrhiza uralensis sprout extracts have shown no cytotoxicity in HepG2 cells. General licorice extracts are considered safe for cosmetic use when formulated appropriately, being non-toxic and non-comedogenic. Oral dose toxicity studies in rats up to 5000 mg/kg/day and AMES tests up to 5000 µg/plate showed no significant toxicological changes or genotoxicity for Glycyrrhiza uralensis varieties. An integrative safety evaluation indicated acceptable dermal safety margins for its key compounds.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Glycyrrhiza uralensis Sprout Extract is a valuable ingredient, offering proven anti-inflammatory, brightening, and antioxidant benefits suitable for a wide range of skin types and concerns with a favorable safety profile.
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