Science
Mechanism of Action
This ingredient operates via several distinct mechanisms to enhance skin health. Primarily, it acts as a powerful antioxidant by effectively scavenging various free radicals, including DPPH, ABTS+, and singlet oxygen, and mitigating lipid peroxidation and H2O2-induced reactive oxygen species (ROS) production. This action protects skin cells from oxidative stress and environmental damage, thereby combating premature aging. Furthermore, GLYCYRRHIZA URALENSIS ROOT PRENYLFLAVONOIDS demonstrate significant anti-inflammatory and soothing effects by reducing redness and irritation, and by inhibiting key inflammatory mediators such as iNOS, pro-inflammatory prostaglandins, and leukotrienes. For skin brightening, certain components like glabridin specifically inhibit tyrosinase activity, which is crucial for melanin production, leading to a reduction in hyperpigmentation and UV-induced discoloration. Additionally, it helps maintain skin elasticity and provides essential conditioning and moisturizing benefits to prevent dehydration.
Research
Clinical Evidence
High confidence0.4%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Prenylflavonoids have shown stability in assays conducted at pH 6.5 for singlet oxygen quenching. Related licorice extracts have been successfully incorporated into cream formulations with pH values ranging from 4.55 to 4.63, indicating good stability within slightly acidic cosmetic environments. The precise optimal pH range for the complete prenylflavonoid complex, however, is not exhaustively defined.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has determined that Glycyrrhiza uralensis root extract, which contains these prenylflavonoids, is safe for use in cosmetics. The FDA recognizes Glycyrrhiza as Generally Recognized as Safe (GRAS) for food consumption. While an in silico prediction for glycyrrhizin, a component, marginally exceeded the Threshold of Toxicological Concern (TTC), it is considered to pose minimal toxicological risk under typical cosmetic application conditions. Liquiritin, another component, exhibits a favorable toxicological profile. It is important to note that large oral intakes of licorice may lead to increased blood pressure and reduced potassium levels. Individuals with sensitive skin or known allergies to licorice should exercise caution.
Your Skin
Skin Compatibility
Our Assessment
Verdict
GLYCYRRHIZA URALENSIS ROOT PRENYLFLAVONOIDS are a valuable multi-functional ingredient offering significant antioxidant, anti-inflammatory, and brightening benefits with a favorable safety and skin compatibility profile across all skin types.
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