Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

GLYCYRRHIZA URALENSIS ROOT EXTRACT.

Valuable CAS 94349-91-4 / SKIN CONDITIONING

Glycyrrhiza Uralensis Root Extract is a multi-functional botanical ingredient recognized for its potent anti-inflammatory, antioxidant, and skin-brightening capabilities. It effectively targets concerns such as hyperpigmentation, redness, and environmental damage, fostering a calmer, more radiant, and even-toned complexion across diverse skin types.

Summary

emollient skin conditioning skin brightening anti-inflammatory antioxidant soothing depigmenting antimicrobial moisturizing toning improves elasticity

Science

Mechanism of Action

This extract exerts its beneficial effects through several key active compounds. Its anti-inflammatory action, primarily attributed to glycyrrhizin, isoliquiritigenin, liquiritigenin, and isoliquiritin, reduces redness and irritation by suppressing nitric oxide activity. As an antioxidant, flavonoids, glabridin, and glycyrrhizin neutralize free radicals, offering protection against environmental stressors and premature aging. For skin brightening, glabridin inhibits tyrosinase, the enzyme responsible for melanin production, while liquiritin helps disperse existing melanin, thereby diminishing hyperpigmentation, dark spots, and melasma. Furthermore, it supports skin elasticity through collagen and elastin regeneration, preserves hyaluronic acid levels, and exhibits antimicrobial, soothing, moisturizing, and toning properties.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Data provided does not suggest this ingredient is commonly dusted or used below an efficacious threshold in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH 3.5 – 9.5
0 7 14

Stability

Glycyrrhizin, a major active compound in licorice, maintains high stability when exposed to temperatures between 100-121°C within a pH range of 4.5-9.5, with reported concentration increases at pH 9.5-4.5 under 100°C. The broader licorice root extract typically exhibits a pH range of 3.5-5.5. It can function as an emulsifier, facilitating the blend of water and oil-based components. To improve the water solubility of specific components like glabridin, advanced formulation techniques such as smartPearls have been developed.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
16%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that glycyrrhizic acid, glycyrrhetinic acid, and related derivatives isolated from Licorice are safe for use in cosmetics. The FDA has granted Generally Recognized As Safe (GRAS) status for licorice and its derivatives in food, at concentrations up to 16%. In silico predictions suggest key G. uralensis components, liquiritin and glycyrrhizin, are 'inactive' for skin sensitization and 'non-irritating'. The EWG Skin Deep database rates common concerns for Glycyrrhiza Uralensis Root Extract as 'LOW' for Cancer and 'LOW_MODERATE' for Allergies & Immunotoxicity and Developmental and Reproductive Toxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Glycyrrhiza Uralensis Root Extract is a valuable ingredient, offering broad-spectrum benefits including anti-inflammatory, antioxidant, and brightening effects, making it highly suitable for diverse skin types and cosmetic formulations.

Related

Similar Ingredients

Finding similar ingredients…