Science
Mechanism of Action
This extract operates through a multifaceted biological pathway to optimize skin health. Its efficacy is largely attributed to key constituents such as glycyrrhizin, which delivers significant anti-inflammatory and soothing benefits. Flavonoids within the extract function as robust antioxidants, effectively neutralizing free radicals to shield the skin from oxidative stress and environmental aggressors. Furthermore, specialized compounds like licoriceidine and licorisoflavan A offer dual anti-inflammatory and antimicrobial advantages. Collectively, these components mitigate redness, irritation, and sensitivity, while simultaneously promoting improved skin tone, texture, and elasticity, rendering it highly effective in anti-aging formulations.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
No available data suggests that Glycyrrhiza Uralensis Callus Extract is commonly 'dusted' or used at sub-efficacious concentrations in cosmetic formulations.
The Formula
Formulation
Stability
The active components of Glycyrrhiza Uralensis Callus Extract are effectively extracted using water/ethanol mixtures, indicating broad solubility in polar solvents. While a specific optimal pH range for this callus extract is not explicitly detailed, studies on cosmetic creams containing Glycyrrhiza uralensis extract have demonstrated pH stability under light exposure, suggesting robustness within typical cosmetic pH ranges. A pH range of 3.5-5.5 has been reported for the stability of a related Glycyrrhiza glabra Root Extract.
Safety
Safety Profile
Glycyrrhiza Uralensis Callus Extract is generally considered safe for topical application. Although the Cosmetic Ingredient Review (CIR) has not yet specifically reviewed this callus extract, the related Glycyrrhiza Uralensis Root Extract is recognized as safe for general or specific, limited use in food by the U.S. Food and Drug Administration (FDA) and possesses established CIR recommendations. In silico analyses of its major constituents, liquiritin and glycyrrhizin, predict favorable dermatological safety, suggesting they are inactive in skin sensitization and non-irritating. While typical exposure levels of glycyrrhizin in face creams might marginally exceed the Threshold of Toxicological Concern (TTC), it is still assessed to pose minimal toxicological risk under standard cosmetic use conditions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
With its broad spectrum of benefits, encompassing potent anti-inflammatory, antioxidant, soothing, and skin-tone evening properties, combined with a favorable safety profile and low irritancy, Glycyrrhiza Uralensis Callus Extract is a valuable active for enhancing skin resilience and aesthetic appearance.
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References
Sources