Science
Mechanism of Action
This extract primarily operates through two distinct pathways. It significantly contributes to skin lightening and depigmentation by inhibiting tyrosinase, the enzyme essential for melanin synthesis, with active components like glabridin reducing the appearance of dark spots. Furthermore, it exhibits potent anti-inflammatory effects, largely due to compounds such as glycyrrhizin, which alleviate redness, irritation, and conditions like atopic dermatitis. Glabridin also provides antioxidant protection against environmental damage.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal formulation stability is typically observed within a pH range of 3.5 to 5.5. This extract is inherently acidic and its incorporation into cream formulations may lead to a decrease in viscosity, likely due to interactions between its polyphenolic and saponin components with the cream base.
Safety
Safety Profile
The FDA recognizes Licorice species as Generally Recognized as Safe (GRAS) for food use. The Cosmetic Ingredient Review (CIR) Expert Panel has deemed Licorice-derived ingredients, including glycyrrhizic acid and glycyrrhetinic acid, safe for cosmetic applications, noting they are generally not dermal irritants, sensitizers, or mutagenic. While generally well-tolerated, some individuals may experience mild irritation, and isolated cases of allergic contact dermatitis have been reported with extracts from related Glycyrrhiza species (e.g., G. inflata). A proposed acceptable daily intake for glycyrrhizin from licorice root and its extracts ranges from 0.015-0.229 mg/kg body weight/day.
Your Skin
Skin Compatibility
Our Assessment
Verdict
GLYCYRRHIZA PALLIDIFLORA ROOT EXTRACT is a valuable multi-functional ingredient, offering significant benefits for skin brightening, anti-inflammation, and antioxidant protection, suitable for a wide range of skin types and formulations.
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