Science
Mechanism of Action
This extract functions primarily as a skin-lightening agent by inhibiting tyrosinase, the enzyme responsible for melanin production, with glabridin identified as a key active compound. Its potent anti-inflammatory properties are linked to compounds like glycyrrhizin and licochalcones, effectively reducing redness and irritation. As an antioxidant, it neutralizes free radicals and protects skin from oxidative stress, thanks to its rich content of flavonoids, isoflavonoids, and dihydrostilbene derivatives. The extract also offers skin-soothing, conditioning, and antimicrobial benefits, potentially improving skin elasticity.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Topical application of 0.5% glabridin (a key active component) effectively inhibited UVB-induced pigmentation.
- 02 2% 18β-glycyrrhetinic acid (an active component) in an ointment demonstrated no negative skin changes, side effects, or sensitization in long-term treatment of dermatoses.
- 03 A 5% aqueous solution of glycyrrhizic acid (an active component) showed no inflammatory reaction on volunteers' skin after 48 hours, even post-irradiation.
- 04 Glycyrrhiza glabra roots at 500 µg/mL exhibited significant antimicrobial potential.
Transparency
Dusting Analysis
The efficacy of Glycyrrhiza Glabra Stem Extract is attributed to specific active compounds such as glabridin, glycyrrhizin, and licochalcones. Clinical data supports the benefits of these components even at relatively low concentrations (e.g., 0.5% glabridin for pigmentation), suggesting that a high overall percentage of the extract may not be necessary to achieve desired effects, provided the extract is standardized for these actives.
The Formula
Formulation
Stability
No specific stability notes provided in the research data.
Safety
Safety Profile
The CIR Expert Panel concluded that all licorice-derived ingredients, including Glycyrrhiza Glabra extracts, are safe for cosmetic use and were not found to be dermal irritants or sensitizers. While generally considered non-toxic and non-comedogenic, some individuals, particularly those with sensitive skin, may experience mild irritation; patch testing is recommended. Risks associated with large oral intake (e.g., increased blood pressure) are not relevant for topical cosmetic application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Glycyrrhiza Glabra Stem Extract is a valuable ingredient, widely recognized for its proven efficacy in brightening, calming, and protecting the skin, making it suitable for a broad range of skin concerns and product types.
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