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GLYCYRRHIZA GLABRA ROOT WATER.

Valuable CAS 84775-66-6 / ANTIOXIDANT, SKIN CONDITIONING

Glycyrrhiza Glabra Root Water, derived from licorice root, is a multi-functional ingredient prized for its significant anti-inflammatory and skin-brightening capabilities. It actively reduces redness and irritation while effectively diminishing hyperpigmentation and dark spots, contributing to a more even-toned complexion. Furthermore, its rich antioxidant profile offers robust protection against environmental stressors.

Summary

antioxidant skin brightening anti-inflammatory soothing antimicrobial

Science

Mechanism of Action

Glycyrrhiza Glabra Root Water exerts its beneficial effects through a complex array of active compounds, including glycyrrhizic acid (glycyrrhizin), glabridin, and various flavonoids. Its anti-inflammatory action is primarily mediated by reducing the generation of inflammatory cytokines, thereby soothing skin irritation and redness. For skin lightening, compounds like glabridin and liquiritin work to inhibit both melanin production and tyrosinase activity, crucial steps in preventing and fading hyperpigmentation. Additionally, its flavonoid content provides powerful antioxidant protection against oxidative damage, complemented by inherent antimicrobial properties.

Research

Clinical Evidence

Medium confidence
Effective range 1–10%
Optimal

N/A

Key findings

  1. 01 Topical application of 0.5% glabridin, an active component within licorice, demonstrated inhibition of UVB-induced pigmentation, highlighting its efficacy in managing hyperpigmentation.
  2. 02 Suggested use levels for 'Water & Glycyrrhiza Glabra (Licorice) Root Extract' in cosmetic formulations fall within this range, supporting its application for conditioning, moisturizing, and anti-aging benefits.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

This ingredient exhibits stability up to 70°C, with optimal storage for extended shelf life occurring between 23-25°C, though it remains stable from 16-32°C. For optimal integration into formulations, it should be incorporated into the water phase of an emulsion or added during the cooling phase (below 50°C) after emulsion formation.

Conflicts

  • acids
  • metallic salts

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has affirmed the safety of all Licorice-derived ingredients, including Glycyrrhiza Glabra Root Water, for use in cosmetics. Safety assessments indicate it is neither a dermal irritant nor a sensitizer and is non-mutagenic. While generally considered non-toxic and non-comedogenic, a patch test is advisable for individuals with highly sensitive skin.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Glycyrrhiza Glabra Root Water is a valuable, multi-functional ingredient, offering significant anti-inflammatory, skin-brightening, and antioxidant benefits across all skin types with a favorable safety profile.

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