Science
Mechanism of Action
This ingredient exerts its skin-lightening effects predominantly through active compounds like glabridin and liquiritin. These compounds inhibit tyrosinase, a key enzyme involved in melanin production, and also facilitate the dispersion and removal of existing melanin. Its anti-inflammatory action is largely attributed to glycyrrhizin and glycyrrhetinic acid, which work to calm redness, irritation, and overall inflammation. Additionally, glabridin, licochalcone A, and other flavonoids provide antioxidant protection against environmental damage and oxidative stress.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Topical application effectively inhibited UVB-induced pigmentation in guinea pigs, highlighting its efficacy in preventing hyperpigmentation.
- 02 A cream formulation demonstrated superior skin brightening effects compared to 20% and 40% concentrations, specifically by reducing spot pigmentation.
- 03 A serum formulation showed optimal facial brightening activity, resulting in a noticeable improvement in skin color.
Transparency
Dusting Analysis
Specific dusting thresholds for Glycyrrhiza Glabra Root Powder itself are not established in the research data. However, clinical efficacy is consistently demonstrated through its extracts or isolated active compounds at concentrations ranging from 0.5% (for the active Glabridin) to 20% (for various licorice extracts). Formulations containing concentrations significantly below these ranges may suggest insufficient active levels for optimal benefit.
The Formula
Formulation
Safety
Safety Profile
Glycyrrhiza Glabra Root Extract is generally considered safe for cosmetic application when properly formulated, exhibiting non-toxicity and low comedogenicity. While typically well-tolerated, rare instances of mild irritation or contact dermatitis may occur in sensitive individuals. The ingredient has been noted to have low neurotoxicity, moderate endocrine disruption potential, and low-to-moderate non-reproductive organ system toxicity by EWG, based on various studies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Glycyrrhiza Glabra Root Powder is a valuable ingredient, offering significant skin brightening, anti-inflammatory, and antioxidant benefits with high skin compatibility and a low risk of irritation or comedogenicity.
Related
Similar Ingredients
Finding similar ingredients…