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GLYCYRRHIZA GLABRA RHIZOME/ROOT EXTRACT.

Valuable CAS 84775-66-6 / SKIN CONDITIONING

Glycyrrhiza Glabra Rhizome/Root Extract, derived from licorice, is a multi-functional botanical celebrated for its potent skin brightening, anti-inflammatory, and antioxidant properties. It effectively addresses hyperpigmentation, calms irritation, and provides essential hydration, contributing to a clearer, more even, and resilient complexion.

Summary

skin brightening anti-inflammatory antioxidant hydrating oil control antimicrobial

Science

Mechanism of Action

This extract operates through several key compounds. Glabridin is a potent tyrosinase inhibitor, directly reducing melanin production to lighten dark spots and diminish hyperpigmentation. Liquiritin and isoliquertin aid in dispersing existing melanin pigment, promoting a uniform skin tone. Glycyrrhizic acid provides significant anti-inflammatory benefits by stimulating endogenous anti-inflammatory mechanisms, maintaining active cortisol, and reducing pro-inflammatory cytokines, which helps alleviate redness, itching, and conditions like eczema and rosacea. Licochalcone further contributes with strong anti-inflammatory and antimicrobial actions, assisting in oil regulation and combating acne-causing bacteria. Additionally, the extract's rich antioxidant profile shields skin from free radical damage and environmental stressors, while its glycyrrhizin content enhances moisture retention, supporting healthy barrier function for hydrated skin.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

10%

Key findings

  1. 01 A 10% licorice extract cream, applied twice daily for four weeks, produced significant improvements in skin brightness and clarity.
  2. 02 Topical application of 0.5% glabridin, a key active component, on guinea pigs effectively inhibited UVB-caused pigmentation.
  3. 03 Clinical trials demonstrated a 30% reduction in dark spots with consistent use over a 12-week period.

Transparency

Dusting Analysis

Not commonly dusted

Clinical studies demonstrate efficacy at specific, documented concentrations (e.g., 10% for overall extract and 0.5% for its active compound glabridin), suggesting that lower, ineffective percentages are less likely to be used for marketing claims without substantiation.

The Formula

Formulation

Solubility
Both
Optimal pH 3.5 – 5.5
0 7 14

Stability

Oil-soluble forms, such as Licorice Oleo Extract, require temperatures below 40ºC to maintain optimal stability.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

Generally considered safe, non-toxic, and non-comedogenic for cosmetic use when appropriately formulated. While regarded as low risk, some individuals with sensitive skin may experience mild irritation or occasional contact dermatitis, thus patch testing is advised.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Glycyrrhiza Glabra Rhizome/Root Extract is a highly valuable multi-active ingredient, providing scientifically supported benefits for brightening, soothing, and protecting all skin types with low risk of irritation or comedogenicity.

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