Science
Mechanism of Action
This advanced extract operates through multiple pathways to enhance skin health. Its primary depigmenting action stems from Glabridin, a key component that inhibits tyrosinase activity, thus reducing melanin synthesis. Concurrently, high concentrations of Glycyrrhizin provide significant anti-inflammatory effects, effectively mitigating redness and irritation. Furthermore, the extract confers robust antioxidant protection against environmental aggressors, ensuring comprehensive skin conditioning.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A targeted study demonstrated that 0.5% Glabridin, a primary active within this extract, significantly inhibited UVB-induced pigmentation in guinea pigs, with comparative efficacy potentially exceeding hydroquinone for skin lightening.
- 02 Licorice root extract, at concentrations ranging from 10-50 µg/mL, promoted a significant increase in human bone marrow mesenchymal stem cell proliferation over 48-72 hours.
- 03 Antimicrobial potential was observed with Glycyrrhiza glabra root extracts at 500 µg/mL, with Glabridin specifically inhibiting Mycobacterium tuberculosis growth at 29.16 µg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Glycyrrhizin, a major component, maintains high stability even under elevated temperatures (100°C-121°C), with increased concentration observed at pH 4.5-9.5 under 100°C. However, polysaccharides and gums within licorice extracts may precipitate in the presence of ethanol.
Conflicts
- Ethanol
Safety
Safety Profile
While a specific Cosmetic Ingredient Review (CIR) for Glycyrrhiza Glabra Meristem Cell Culture Extract is not available, the well-established safety profile of Glycyrrhiza Glabra Root Extract indicates it is safe for cosmetic application, non-toxic, and non-comedogenic. Isolated reports of mild irritation in highly sensitive individuals suggest precautionary patch testing may be advisable. Moreover, licorice (Glycyrrhiza glabra) holds FDA Generally Recognized As Safe (GRAS) status for food flavoring.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Glycyrrhiza Glabra Meristem Cell Culture Extract is a valuable, multi-functional ingredient offering scientifically backed benefits for brightening, soothing, and protecting the skin, leveraging the well-documented efficacy of its constituent compounds.
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References
Sources