Science
Mechanism of Action
This derivative actively conditions the stratum corneum, functioning as a humectant to draw and retain moisture, thereby reducing epidermal flaking and promoting dermal suppleness. Its mechanism extends to modulating inflammatory responses by inhibiting reactive oxygen species (ROS) generation within neutrophils and regulating key inflammatory mediators such as cyclooxygenase-2 (COX-2), while concurrently providing antioxidant defense.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Evaluated by the Cosmetic Ingredient Review (CIR) Expert Panel, Glycyrrhetinyl Stearate is deemed safe under current conditions of use and concentration. Studies indicate minimal percutaneous absorption, with no evidence suggesting irritant, sensitizing, phototoxic, or photosensitizing effects. Furthermore, the U.S. Food and Drug Administration (FDA) includes licorice derivatives, such as Glycyrrhetinyl Stearate, on its Generally Recognized As Safe (GRAS) list.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Glycyrrhetinyl Stearate is a valuable ingredient, offering significant skin conditioning, humectant, anti-inflammatory, and antioxidant benefits, particularly beneficial for dry and sensitive skin types.
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References
Sources