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Moumoujus

GLYCINAMIDE HCL.

Valuable CAS 1668-10-6 / SKIN CONDITIONING, SKIN PROTECTING

Glycinamide HCL is a highly stable, water-soluble compound that functions as a potent skin conditioning and protecting agent. It specifically targets hyperpigmentation by reducing melanin synthesis, leading to a more even and brighter complexion.

Summary

Skin conditioning Skin protecting Depigmenting agent

Science

Mechanism of Action

This active ingredient operates through multiple pathways. Primarily, it conditions and protects the skin by forming a barrier against environmental stressors, enhancing texture and overall appearance. As a depigmenting agent, Glycinamide HCL effectively suppresses key signaling pathways in melanogenesis: it inhibits the activation of cAMP-responsive element-binding protein (CREB) and reduces the mRNA expression of microphthalmia-associated transcription factor (MITF) and tyrosinase (TYR) in response to α-melanocyte stimulating hormone (α-MSH), ultimately decreasing melanin production.

Research

Clinical Evidence

Medium confidence
Effective range 10–10%
Optimal

10%

Key findings

  1. 01 In human clinical trials, a 10% concentration demonstrated no adverse skin responses during primary irritation tests. Sustained application led to a significant reduction in melanin index and increased skin lightness (L* value) and color (ITAo) after two weeks, with prominent depigmentation observed within six to eight weeks, without signs of irritation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Glycinamide HCL is highly stable and water-soluble, allowing for straightforward integration into diverse cosmetic formulations. It maintains chemical stability under standard ambient conditions at room temperature.

Conflicts

  • Strong oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Glycinamide HCL is generally considered safe for topical application in cosmetic products, with a 10% solution showing no irritation in human trials. While raw material safety data sheets indicate it does not meet acute toxicity or skin/eye irritancy criteria for regulations, some GHS data may refer to concentrated chemical forms. Due to limited data on topical use during pregnancy and breastfeeding, consultation with a healthcare professional is recommended for these individuals.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Glycinamide HCL is a valuable ingredient for improving skin tone and texture, offering proven depigmenting effects alongside general skin conditioning, with excellent compatibility across all skin types.

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