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Moumoujus

GLYCEROL FORMAL.

Avoid CAS 4740-78-7 / ANTIMICROBIAL

Glycerol Formal functions as a versatile solvent and carrier, capable of dissolving a wide range of both polar and non-polar active ingredients. In topical applications, it demonstrates potential to enhance the penetration of lipophilic actives into the skin.

Summary

Solvent Carrier Solubilizer Penetration Enhancer Stabilizer

Science

Mechanism of Action

This compound primarily acts by solubilizing a broad spectrum of active ingredients, facilitating their stable incorporation into formulations. When applied topically, it has been explored for its ability to improve the dermal absorption of lipophilic compounds, thereby enhancing their delivery. It may also contribute to the stability of active ingredients and modulate their release profiles.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest that Glycerol Formal is subject to 'dusting' or exaggerated marketing claims concerning its efficacy in skincare applications.

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

Glycerol Formal exhibits chemical stability across a broad range of pH and temperatures. However, it is hygroscopic, meaning it readily absorbs moisture, which can potentially affect formulation stability and shelf life. Formulations containing Glycerol Formal should be stored away from heat sources, direct sunlight, and humidity to maintain integrity.

Synergies

  • Enhances the dermal penetration and delivery of lipophilic active ingredients.

Conflicts

  • Strong oxidizers
  • Strong acids
  • Potential interactions with certain active pharmaceutical ingredients (APIs) under specific conditions

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Moderate

Glycerol Formal is not classified as GRAS (Generally Recognized As Safe) by the FDA for human pharmaceutical or food use; its inclusion in human pharmaceutical formulations requires case-by-case evaluation. While toxicological evaluations primarily for veterinary use indicate low acute toxicity in animal models when properly purified, Safety Data Sheets indicate it 'Causes serious eye irritation' and 'Causes skin irritation,' and 'May cause a slight irritation in skin and eyes for repeated contact.' Crucially, it is 'Suspected of damaging the unborn child' and 'Suspected of damaging fertility.' Strict control of residual formaldehyde levels during manufacturing is paramount.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to significant safety concerns, including suspected reproductive toxicity and moderate skin irritancy, Glycerol Formal is not recommended for use in precision skincare formulations.

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