Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

GLUCOSYL PENTAGALLATE.

Optional CAS 14937-32-7 / ANTIOXIDANT

Glucosyl Pentagallate is an innovative ingredient recognized for its robust antioxidant and anti-inflammatory properties. It actively supports skin health by stabilizing vital structural proteins like elastin and collagen, while also preventing the degradation of key extracellular matrix components such as hyaluronic acid.

Summary

Antioxidant Anti-inflammatory ECM Stabilizer Collagen Support Elastin Support Hydration Support

Science

Mechanism of Action

This ingredient functions primarily as a potent antioxidant, effectively neutralizing reactive oxygen species (ROS) that contribute to cellular damage and premature aging. It exhibits anti-inflammatory effects and helps maintain the structural integrity of the arterial extracellular matrix (ECM) by stabilizing elastin and collagen fibers in vascular tissues. Furthermore, Glucosyl Pentagallate reduces matrix metalloproteinase-2 (MMP-2) expression, an enzyme involved in ECM degradation, and helps preserve components like hyaluronic acid, thereby aiding in proper skin hydration.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In an in vitro study on rat aortic smooth muscle cells, Glucosyl Pentagallate significantly increased elastin fiber synthesis and lysyl oxidase activity, while simultaneously decreasing matrix metalloproteinase-2 (MMP-2) levels.
  2. 02 Another in vitro study demonstrated Glucosyl Pentagallate's potent antioxidant capabilities, achieving a 75% inhibition of reactive oxygen species (ROS).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 5 – 6
0 7 14

Stability

Glucosyl Pentagallate exhibits optimal stability within a pH range of 5.0 to 6.0, with degradation observed at pH 7.0. It possesses poor water solubility, estimated at 0.1885 mg/L at 25 °C, but is soluble in organic solvents such as DMSO and ethanol.

Conflicts

  • Can cause protein precipitation.
  • Solubility may be reduced by moisture-absorbing DMSO.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

There is no explicit CIR or SCCS review information available. The ingredient has an FDA UNII (3UI3K8W93I). GHS classification according to OSHA HCS indicates no identified hazards, hazard statements, or precautionary statements, with oral, dermal, and inhalation toxicities currently undetermined.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Optional

Glucosyl Pentagallate is a promising antioxidant and ECM-supporting ingredient with in vitro evidence for anti-aging and firming benefits, though further human in vivo data would strengthen its profile for precision skincare.

Related

Similar Ingredients

Finding similar ingredients…