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Moumoujus

GLUCOSYL CERAMIDE NP.

Valuable / HAIR CONDITIONING, HUMECTANT

Glucosyl Ceramide NP is a crucial lipid precursor and structural component found within the skin's stratum corneum. It actively replenishes depleted natural lipids, significantly enhancing moisture retention and fortifying the skin's protective barrier against environmental aggressors, leading to visibly healthier and more resilient skin.

Summary

Emollient Moisturizer Skin-identical ingredient Barrier-strengthening Anti-inflammatory Hydration enhancement Sensitivity reduction TEWL reduction

Science

Mechanism of Action

As a vital building block, Glucosyl Ceramide NP integrates into the stratum corneum, restoring and maintaining its structural integrity. It effectively reduces transepidermal water loss (TEWL) by forming a robust, water-tight barrier, thereby locking in moisture and preventing the intrusion of harmful external substances. This action strengthens the skin's defense, supports healthy epidermal formation, minimizes inflammation, and mitigates factors associated with sensitivity, dryness, and dullness.

Research

Clinical Evidence

High confidence
Effective range 0.05–5%
Optimal

0.5%

Key findings

  1. 01 Studies on related Ceramide NP demonstrate significant skin barrier recovery and enhanced moisture retention within days at concentrations from 0.05% to 1.0%, leading to smoother, softer, and healthier-looking skin. This efficacy is often optimized when combined with cholesterol and free fatty acids in a 3:1:1 ratio.
  2. 02 Typical cosmetic formulations incorporate related Ceramide NP at 0.5% to 5%, mirroring its natural abundance in the skin. This range has been shown to boost skin hydration by up to 38% over four weeks and facilitate the repair of sensitive or compromised skin.
  3. 03 A 3% blend of ceramides, including related Ceramide NP, cholesterol, and fatty acids, has been clinically observed to improve skin hydration in mature skin.
  4. 04 A facial cream containing related Ceramide NP, alongside Centella asiatica and panthenol, provided immediate relief from redness and discomfort. Over four weeks, it significantly enhanced skin barrier strength, balanced pH, and regulated sebum production.

Transparency

Dusting Analysis

Not commonly dusted

The provided research data does not contain information regarding 'dusting' or ineffective low concentrations for Glucosyl Ceramide NP. Efficacy is observed at relatively low percentages for related ceramides.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Related Ceramide NP is susceptible to environmental degradation from factors like temperature, humidity, and light. Despite its oil solubility, it is often incorporated into the water phase of emulsions. Its chemical structure, poor aqueous solubility, and high molecular weight can pose formulation challenges.

Synergies

  • Often combined with cholesterol and free fatty acids in a 3:1:1 ratio for enhanced barrier recovery.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
10%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel deems ceramide ingredients, including related Ceramide NP, safe for cosmetic use up to 10% concentration. It is non-irritating and does not induce sensitization. Products containing ingredients derived from bovine central nervous system tissues are prohibited in cosmetics.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Glucosyl Ceramide NP is a valuable skin-identical ingredient that significantly strengthens the skin barrier, enhances hydration, and reduces sensitivity, making it ideal for a wide range of skin types and concerns.

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