Science
Mechanism of Action
The extract's efficacy is attributed to its rich phytochemical composition, encompassing flavonoids, saponins, tannins, alkaloids, polyphenols, glycosides, and volatile oils. These compounds work synergistically, providing significant antimicrobial action against both bacteria and fungi. As an anti-inflammatory agent, it reduces discomfort and bleeding by inhibiting cyclooxygenase (COX) and lipoxygenase enzymes, thereby decreasing leukocyte accumulation and inhibiting histamine release. It also offers antioxidant protection by scavenging free radicals. Its capacity to promote wound healing is linked to enhancing the healing cascade, reducing inflammatory cell presence, and downregulating pro-inflammatory cytokines such as IL-1β and IL-6.
Research
Clinical Evidence
Medium confidence7.5%
Key findings
- 01 A gel formulation demonstrated effectiveness as a wound healing agent.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Aqueous extracts are commonly prepared, indicating water solubility. A gel formulation containing the extract exhibited stability across a pH range of 5 to 10 and maintained its organoleptic properties and pH for at least two years.
Safety
Safety Profile
Although not assessed by CIR, SCCS, or FDA, studies indicate 'no cytotoxicity' for the extracts. A 7.5% gel formulation for wound healing was found to be 'safe, effective, stable and low cost', with traditional uses suggesting fewer adverse effects compared to some conventional treatments.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Gliricidia Sepium Leaf Extract is a valuable botanical ingredient offering robust antimicrobial, anti-inflammatory, and wound-healing benefits, particularly suited for sensitive and oily skin concerns.
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