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Moumoujus

GINSENOSIDE RD.

Valuable CAS 52705-93-8 / ANTIOXIDANT

Ginsenoside Rd is a powerful triterpene saponin extracted from ginseng, distinguished by its robust antioxidant and anti-inflammatory capabilities. It actively safeguards skin cells from environmental damage, stimulates cellular regeneration, and promotes overall skin vitality, positioning it as a key ingredient for advanced skincare solutions.

Summary

Antioxidant Anti-inflammatory Anti-photoaging Wound Healing Collagen Boosting Skin Brightening Skin Conditioning

Science

Mechanism of Action

This compound primarily functions as an antioxidant by significantly reducing UV-B induced Reactive Oxygen Species (ROS) generation and up-regulating endogenous antioxidant enzymes such as Superoxide Dismutase (SOD) and Glutathione (GSH). It further combats photoaging by diminishing pro-matrix metalloproteinase-2 (proMMP-2) activity. Ginsenoside Rd also enhances wound healing by accelerating keratinocyte progenitor cell proliferation and migration, improving cAMP generation and CREB phosphorylation, and elevating collagen type I levels. Its comprehensive benefits extend to general anti-aging, including protection against skin irritation, immune function enhancement, melanin formation resistance, and potential increases in collagen and hyaluronic acid.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In HaCaT keratinocytes, concentrations of 5 μM, 12 μM, and 30 μM attenuated UV-B induced Reactive Oxygen Species (ROS) generation and pro-matrix metalloproteinase-2 (proMMP-2) activity, while augmenting total Superoxide Dismutase (SOD) and Glutathione (GSH) levels, demonstrating significant anti-photoaging protection.
  2. 02 At cellular levels, 0.1 μM, 1 μM, and 10 μM concentrations promoted wound healing by accelerating keratinocyte progenitor cell proliferation and migration, improving cAMP generation and cAMP-response element binding protein (CREB) phosphorylation, and elevating collagen type I production.
  3. 03 Topical application of 5 mg/mL in a 20% ethanol and methanol mixture in C57BL/6 mice accelerated cell proliferation during both the anagen and telogen phases of hair follicles, confirming its wound healing properties.

Transparency

Dusting Analysis

Not commonly dusted

No specific data available to assess dusting practices or thresholds for Ginsenoside Rd in formulations.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Ginsenoside Rd demonstrates reduced stability under highly acidic conditions (specifically pH 3.0) and at elevated temperatures exceeding 100°C. Biotransformation from related ginsenosides to Rd is most efficient at pH 6.0 and 52.5°C.

Conflicts

  • strong acidic conditions (pH 3.0)
  • high temperatures (above 100°C)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Ginsenoside Rd has not undergone specific safety review by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS). While a GRAS notice for general Korean red ginseng root extract was withdrawn from the FDA, broader Panax ginseng extracts have generally shown no evidence of toxicity in certain contexts. Specific irritancy and comedogenicity data for Ginsenoside Rd are currently unknown.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Ginsenoside Rd is a valuable ingredient for advanced skincare, offering significant potential in anti-aging, photo-protection, and wound healing, supported by promising cellular and in-vivo studies.

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