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Moumoujus

GINKGO LEAF TERPENOIDS.

Insufficient Data CAS 90045-36-6 / ANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING

Ginkgo Leaf Terpenoids, encompassing ginkgolides and bilobalides, are potent plant-derived compounds offering comprehensive skin benefits. They meticulously combat oxidative stress, visibly reducing signs of aging, while simultaneously promoting a calmer, more even, and revitalized complexion.

Summary

Antioxidant Anti-inflammatory Soothing Moisturizer Anti-aging Microcirculation enhancement Collagen support Antimicrobial

Science

Mechanism of Action

These potent terpenoids function primarily as robust antioxidants, meticulously neutralizing free radicals and repairing existing cellular damage. They exert significant anti-inflammatory and soothing effects, while specifically preventing the demise of melanin-producing cells (melanocytes) and inhibiting reactive oxygen species, collectively contributing to diminishing hyperpigmentation and refining skin tone. Key components like Ginkgolide K upregulate VEGF, enhancing microcirculation for improved cellular oxygenation and radiance, concurrently stimulating collagen synthesis for improved elasticity and exhibiting antimicrobial properties.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Commonly dusted
Min. effective
less than 5 ppm%

The Cosmetic Ingredient Review (CIR) Expert Panel highlights a critical concern regarding the impurity ginkgolic acid in Ginkgo biloba extracts. Good manufacturing practices are essential to strictly limit its concentration to below 5 ppm, as levels exceeding this threshold are recognized as potentially hazardous compounds.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

Optimal stability is observed within a pH range of 4.5-6.5. Formulations utilizing a natural deep eutectic system for Ginkgo biloba extract demonstrated consistent antioxidant activity and stability for over 360 days, suggesting robust stability in cosmetic applications.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that data for 'Ginkgo Leaf Terpenoids' were insufficient to determine safety under the intended conditions of use in cosmetic formulations as of 2018. The primary concern is the presence of ginkgolic acid, an identified hazardous impurity, which necessitates adherence to strict good manufacturing practices to ensure its concentration remains under 5 ppm.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Insufficient Data

While exhibiting strong mechanistic benefits and promising clinical observations for anti-aging and complexion improvement, a conclusive safety assessment by the CIR Expert Panel remains pending due to insufficient data and crucial concerns regarding ginkgolic acid impurity.

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