Science
Mechanism of Action
As active constituents of Ginkgo Biloba extract, Ginkgo Biflavones deliver robust antioxidant protection by neutralizing free radicals generated by UV radiation, pollution, and blue light, thereby safeguarding against premature skin aging and collagen degradation. They exhibit significant anti-inflammatory actions, effectively calming redness and soothing sensitive or irritated skin, potentially through the modulation of inflammatory pathways like JAK2/STAT3. Furthermore, this ingredient is known to improve skin microcirculation, facilitating enhanced delivery of vital nutrients and oxygen to dermal cells while aiding in toxin removal, which contributes to a clearer, more uniform complexion. It also stimulates collagen and elastin synthesis, improving skin elasticity and diminishing the appearance of fine lines and wrinkles, and promotes cellular renewal for a revitalized look. Emerging evidence also points to antibacterial properties against common skin pathogens and a supportive role in enhancing skin hydration and aiding regeneration and wound healing.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In a two-week human trial, topical application of a cream containing Ginkgo Biloba Leaves Extract (which includes biflavones) was found to be effective and safe, demonstrating significant free radical scavenging, enhancing skin vitality and tautness, reducing wrinkles, and improving overall skin shape and texture.
- 02 Standardized Ginkgo biloba extract (EGb 761) containing 24% flavonoid glycosides (biflavones) has shown antioxidant and anti-inflammatory benefits, underscoring the contribution of biflavones to these effects.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Ginkgo Biloba Leaf Extract, which contains biflavones, is advised to be incorporated into formulations at temperatures below 50°C to maintain stability.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel concluded that specific data for 'Ginkgo Biflavones' alone are insufficient to establish safety under intended cosmetic use, citing a lack of information on manufacturing, composition, impurities, dermal toxicity, irritation, and sensitization. For the broader 'Ginkgo Biloba Leaf Extract' (which contains biflavones), clinical studies have reported no adverse effects at concentrations up to 1.5%. While a specific Ginkgo biloba leaf extract (not 'Ginkgo Biflavones') was linked to carcinogenic activity in mice at high oral doses by NTP, the CIR Panel deemed these findings irrelevant to cosmetic applications due to significant differences in concentration and route of administration. Overall, Ginkgo Biloba Leaf Extract is generally regarded as safe for cosmetic use with a low potential for irritation or sensitization at recommended concentrations. No specific SCCS opinion exists for 'Ginkgo Biflavones'.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Ginkgo Biflavones offer valuable antioxidant and anti-inflammatory benefits for comprehensive skin rejuvenation and protection, despite the Cosmetic Ingredient Review noting insufficient specific data for the isolated compound.
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References
Sources