Science
Mechanism of Action
Geranium Macrorrhizum Herb Extract operates through several pathways: it exhibits antimicrobial and antibacterial activity, effectively reducing the proliferation of microorganisms that can cause breakouts and irritation. Its anti-inflammatory effects are notable, evidenced by its influence on pro-inflammatory mediators such as TNF-α. The extract provides antioxidant protection by scavenging free radicals, attributed to its rich phenolic compound content. Additionally, it acts as an astringent, helps regulate sebum production to prevent clogged pores, and promotes wound healing by stimulating tissue regeneration and collagen synthesis, aiding in the repair of damaged skin and reducing scar visibility. It also contributes to maintaining the skin’s natural moisture balance.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 An essential oil concentration of 0.4-1.0 µg/mL demonstrated strong and selective antibacterial activity against Bacillus subtilis in vitro, with germacrone identified as a principal bioactive compound.
- 02 In vivo and in vitro tests utilizing various concentrations of extracts indicated no significant genotoxicity.
- 03 In vitro research suggests anti-inflammatory potential, demonstrated by its influence on TNF-α.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The CO2 extract form is highly viscous and benefits from gentle heating to facilitate blending with lipids and vegetable oils. It is generally considered stable.
Conflicts
- strong oxidants
Safety
Safety Profile
This ingredient has not been specifically reviewed by CIR or SCCS. In vivo and in vitro tests of various Geranium macrorrhizum extracts have shown no significant genotoxicity. The median lethal dose (LD50) for cranesbill oil (which includes G. macrorrhizum oil) is reported as >5000 mg/kg in rats via oral toxicity studies, indicating a generally low systemic toxicity for broad applications. However, direct contact with the solid or liquid form may cause potential irritation to the skin, eyes, or respiratory system, and it is flammable, posing a burning risk when in contact with strong oxidants.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Geranium Macrorrhizum Herb Extract is a valuable ingredient, providing a comprehensive range of benefits including antimicrobial, anti-inflammatory, and antioxidant actions, making it well-suited for diverse skin concerns from acne management to supporting skin recovery, with a generally favorable safety profile.
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