Science
Mechanism of Action
This extract operates through its rich content of phenolic compounds and flavonoids. These components effectively scavenge free radicals and absorb UV light, thereby mitigating oxidative stress, preventing photoaging, and supporting overall skin health. Additionally, it demonstrates anti-inflammatory action by reducing nitric oxide production, cyclooxygenase-2 (COX-2) activity, and proinflammatory cytokines in cellular models. Its natural humectant qualities further support skin barrier function by helping to retain moisture in cosmetic formulations.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies indicate significant antioxidant efficiency of a hydromethanolic extract, with an IC50 (concentration for 50% inhibition) ranging from 10.79 ± 0.49 to 74.09 ± 1.83 µgmL⁻¹.
- 02 A hydromethanolic extract demonstrated promising efficacy in protecting against UVB radiation, reporting an SPF value of 19 ± 0.5.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Active compounds in the extract are susceptible to degradation from light and heat. Advanced formulation strategies, such as the development of more stable derivatives or encapsulation in liposomes, may be necessary to protect active substances from degradation and maintain efficacy.
Safety
Safety Profile
No in silico skin irritant effects were detected for the hydromethanolic extract. However, formal safety assessments by regulatory bodies such as CIR, SCCS, or FDA are not yet available for Garcinia Subelliptica Leaf Extract.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A valuable botanical ingredient offering diverse benefits including antioxidant protection, anti-inflammatory support, and hydration, though further in-vivo human studies and formal safety reviews would enhance its precision applications.
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References
Sources