Science
Mechanism of Action
This powder functions as a powerful antioxidant, neutralizing oxygen-driven reactions that lead to cellular damage. It specifically targets UVA-induced photoaging by reducing intracellular Reactive Oxygen Species (ROS) production, downregulating Matrix Metalloproteinase-1 (MMP-1) expression, and preventing collagen I degradation. Furthermore, it combats skin senescence by decreasing SA-β-Gal expression, supporting healthy cell turnover. Its active xanthone compounds also confer anti-inflammatory, antimicrobial, and antibacterial effects against common skin pathogens like Staphylococcus aureus and Cutibacterium acnes, while also exhibiting anti-elastase, anti-hyaluronidase, and anti-tyrosinase activities for comprehensive anti-aging and anti-hyperpigmentation benefits.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A mangosteen pericarp extract at 50 µg/mL effectively inhibited UVA-induced photoaging in fibroblasts, demonstrating significant antioxidation, anti-senescence, and anti-photoaging effects by reducing ROS, MMP-1 expression, collagen I degradation, and SA-β-Gal expression.
- 02 An extract concentration of 0.19 mg/mL demonstrated an antioxidant effect (IC50) in a natural face serum formulation.
- 03 Antibacterial properties were observed against Staphylococcus aureus with an 18.03 mm zone of inhibition when the extract was incorporated into a natural face serum.
- 04 The extract exhibited antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) with Minimum Inhibitory Concentrations (MIC) ranging from 0.02 to 1.25 mg/mL and Minimum Bactericidal Concentrations (MBC) from 0.03 to 5 mg/mL.
- 05 Alpha-mangostin, a key component, showed antibacterial activity against methicillin-susceptible and methicillin-resistant S. pseudintermedius at concentrations as low as 0.53 µg/mL and 0.47 µg/mL, respectively.
- 06 A mangosteen pericarp extract at 100% significantly inhibited biofilm formation by S. mutans and P. gingivalis.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The active compounds, particularly xanthones, are generally lipophilic with low water solubility, which may necessitate advanced delivery systems like nanoemulsions for enhanced skin penetration and bioavailability. Milling the pericarp powder can improve its solubility. Formulations maintaining a pH between 4.7 and 4.8 have shown optimal stability.
Safety
Safety Profile
The ingredient is listed on INCI Beauty with 'No penalty' in all categories. Predictive toxicology for alpha-mangostin, a major component, suggests it is a non-irritant to the skin but a mild ocular irritant. It is predicted non-mutagenic and non-carcinogenic in female rats, though potentially carcinogenic in male rats. An in vitro study found no significant cytotoxicity of mangosteen pericarp extract on primary human dermal fibroblasts at concentrations up to 50.0 µg/mL.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Garcinia Mangostana Pericarp Powder is a valuable multi-functional ingredient offering significant antioxidant, anti-aging, and antimicrobial benefits for comprehensive skin health and protection.
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References
Sources