Science
Mechanism of Action
This ingredient, especially its peel, delivers a wealth of bioactive compounds including various phenolic compounds (such as epicatechin, procyanidin, xanthones, and tannins) and citric acid. These compounds collectively contribute to its robust antioxidant capabilities by significantly reducing reactive oxygen and nitrogen species (RONS). Furthermore, its anti-inflammatory action is evidenced by its ability to decrease UVB-induced IL-6 production. Traditionally valued for its skin healing and nourishing attributes, Garcinia humilis also demonstrates potential in mitigating signs of skin aging influenced by inflammation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Garcinia humilis peel extracts demonstrated dose-dependent anti-melanoma activity on MM418C1 and D24 cancer cells, with IC50 values ranging from 130-200 μg/mL and 122-176 μg/mL respectively, showing minimal effect on control fibroblast cells.
- 02 An extract (concentration 10-25 mg/L) significantly reduced reactive oxygen and nitrogen species (RONS) production in keratinocytes, achieving 50% inhibition at the highest concentration. It also decreased UVB-induced IL-6 production when used as pre-treatment at 25 mg/L and post-treatment at 10 mg/L and 25 mg/L.
Transparency
Dusting Analysis
No information regarding dusting potential was found in the available research data for this ingredient.
The Formula
Formulation
Stability
Extracts from Garcinia humilis peel maintain increased antioxidant activity and remain microbiologically safe and relatively stable for at least two weeks when integrated into moisturizing creams. Effective extraction of its phenolic compounds is achieved using ethanol:water mixtures (e.g., 90:10, 70:30, 50:50).
Safety
Safety Profile
Preparations of Achachairu (Garcinia humilis) have been shown to be non-cytotoxic in vitro at concentrations relevant for finished product formulation. In vitro tests did not identify them as potential skin sensitizers. Achachairu seed extract exhibited no genotoxicity in various mammalian cells at concentrations up to 2000 mg kg⁻¹, though specific toxicity data for the fruit peel were not reported.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Garcinia humilis fruit/peel/seed powder is a valuable ingredient, demonstrating potent antioxidant and anti-inflammatory benefits with a low sensitization risk, making it suitable for formulations targeting skin protection and repair.
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References
Sources