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Moumoujus

GALLIUM MALTOLATE.

Valuable CAS 108560-70-9 / SKIN CONDITIONING

Gallium Maltolate is an advanced compound that delivers gallium (Ga3+) to the skin, leveraging its unique ability to mimic ferric iron (Fe3+). This modulates various iron-dependent biological pathways, offering potential benefits for skin lightening, anti-inflammatory effects, and cellular regulation.

Summary

Skin conditioning Skin lightening Anti-inflammatory Antimicrobial Antiproliferative

Science

Mechanism of Action

Gallium Maltolate delivers Ga3+, which structurally mimics Fe3+. This enables Ga3+ to competitively bind and displace Fe3+ from vital iron-mediated enzymatic reactions, disrupting cellular iron homeostasis. Unlike Fe3+, Ga3+ is redox-inactive, preventing participation in iron-dependent redox processes. This action inhibits enzymes like ribonucleotide reductase, crucial for DNA synthesis, leading to antiproliferative effects. It also exhibits anti-inflammatory activity, potentially by down-regulating pro-inflammatory T-cells and inhibiting inflammatory cytokine secretion from macrophages. Further interactions may include matrix metalloproteinases, substance P, and inhibition of mitochondrial complex I, reducing cellular oxygen consumption and increasing ROS.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Gallium Maltolate is a specialized active ingredient and not typically associated with being 'dusted' in cosmetic formulations.

The Formula

Formulation

Solubility
Both
Optimal pH 5.5 – 8
0 7 14

Stability

A dilute aqueous solution of Gallium Maltolate demonstrates high stability with minimal dissociation within the pH range of 5.5 to 8.0. At neutral pH, the molecule maintains an electrically neutral charge, which contributes to its stability.

Conflicts

  • Due to its iron-mimicking mechanism, potential antagonistic interactions with iron-containing ingredients are implied for topical formulations, though not explicitly stated for cosmetic use. Known drug interactions include oral iron supplements or iron chelators.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.5%
Sensitization risk Low

Gallium Maltolate has been granted 'Orphan Drug Designation' by the FDA for glioblastoma, which is a pharmaceutical classification and not a cosmetic ingredient status. Phase 1 oral clinical trials for this medical application indicated low toxicity and good tolerability with no major negative reactions. A 0.5% topical formulation reported no skin irritation or side effects.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Gallium Maltolate presents a valuable and unique mechanism for skincare, particularly for its potential in skin lightening and anti-inflammatory applications, though further dedicated topical efficacy studies are warranted.

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