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Moumoujus

GALIUM APARINE EXTRACT.

Valuable CAS 84625-42-3 / SKIN CONDITIONING

Galium Aparine Extract, derived from the Cleavers plant, is a multi-functional botanical celebrated for its traditional use in detoxification and soothing treatments. This extract demonstrates notable immunomodulatory, antioxidant, and anti-inflammatory benefits, actively promoting wound healing and providing hydration for compromised or irritated skin conditions.

Summary

Skin Conditioning Immunomodulatory Antioxidant Anti-inflammatory Wound Healing Hydrating Detoxifying Support Soothing Antibacterial

Science

Mechanism of Action

Galium Aparine Extract modulates skin health through several synergistic pathways. It enhances the skin's host-dependent defense mechanisms by exhibiting immunomodulatory activity, which is advantageous for addressing skin infections and supporting wound recovery. The extract’s antioxidant properties effectively mitigate oxidative stress by reducing free radicals and reactive oxygen species, thereby contributing to cellular protection and potentially slowing intrinsic aging processes. It provides anti-inflammatory support, traditionally acting as a lymphagogue to improve lymphatic circulation, decrease stagnation, and aid in the elimination of metabolic waste, which collectively helps to restore tissue balance. Furthermore, it possesses antibacterial potential and actively promotes wound healing by stimulating cell migration and proliferation. The presence of silica contributes to its demulcent action, reinforcing connective tissue structure, while short-term application delivers moistening effects, hydrating dry and irritated tissues to cool and lessen irritation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Aqueous extract demonstrated significant in vitro immunostimulatory activity, registering 1.36 times higher than the reference PHA.
  2. 02 Ethanolic extracts displayed the highest in vitro immunostimulatory activity.
  3. 03 Exhibited superior potency in in vitro wound healing, achieving nearly 100% effects within 24 hours in NHDF and HUVEC cell lines. It also proved effective at 50 mg/mL, outperforming allantoin.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Galium aparine is rich in water-soluble constituents, making water or moderate alcohol concentrations (e.g., 30-50%) optimal for extraction; high-proof alcohol may be less effective. While an isolated alkaline protease from Galium aparine exhibited optimal activity at pH 8.0, this does not directly indicate the stability of the full extract. Related Galium verum extracts have shown stability in emulsions between pH 4.99 and 5.04. For medicinal preparations, the fresh herb is often preferred due to its high water content.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not extensively evaluated Galium Aparine Extract for cosmetic safety, citing 'No Reported Uses' under the FDA's Voluntary Cosmetics Reporting Program. However, EWG Skin Deep rates it as a 'Low' concern for cancer, allergies & immunotoxicity, and developmental & reproductive toxicity, though based on limited to fair data. While topical use generally appears safe with a low irritancy rating, internal use carries contraindications for individuals with high blood pressure, those on blood thinners or diuretics, or long-term medications.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Galium Aparine Extract is a valuable botanical ingredient offering robust *in vitro* wound healing, immunomodulatory, and antioxidant benefits, making it particularly advantageous for supporting dry and sensitive skin types.

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