GALACTOMYCES/PHELLINUS LINTEUS EXTRACT FERMENT FILTRATE.

This ingredient operates primarily through its Galactomyces Ferment Filtrate (GFF) component, which delivers a rich spectrum of nutrients including amino acids, vitamins, minerals, and enzymes. GFF functions as a potent antioxidative aryl hydrocarbon receptor (AHR) agonist, thereby upregulating filaggrin expression—a critical source of natural moisturizing factors—and activating nuclear factor erythroid-2-related factor 2 (NRF2) for robust antioxidant defense. It precisely modulates cellular pathways by downregulating CDKN2A, a marker associated with senescent keratinocytes, and enhances epidermal terminal differentiation by upregulating caspase-14, claudin-1, and claudin-4. Furthermore, GFF exerts immunomodulatory effects, promoting the anti-inflammatory cytokine IL-37 while downregulating the proallergic cytokine IL-33, and mitigating inflammaging by reducing CXCL14 and IL6R gene expression. The Phellinus Linteus extract component complements these actions with its established anti-inflammatory and antioxidant properties.