Science
Mechanism of Action
Galactomyces/Milk Ferment Filtrate operates through several pathways to optimize skin health. It provides a potent blend of nutrients and antioxidants, crucial for cellular function and hydration by stimulating hyaluronan production in epidermal cells. GFF actively boosts the skin barrier by activating the aryl hydrocarbon receptor (AhR) and upregulating key epidermal proteins like filaggrin, loricrin, and claudin-1 and -4. Its significant antioxidant capacity stems from activating nuclear factor erythroid-2-related factor 2 (NRF2), which subsequently increases antioxidative enzymes such as NQO1 and HMOX1, thereby combating oxidative stress. Furthermore, GFF supports skin cell regeneration, rebalances the skin's microbiome, and contributes to an even skin tone by inhibiting factors linked to hyperpigmentation, while also exhibiting anti-inflammatory and anti-aging properties.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 In a study involving 20 volunteers, a 97% concentration significantly reduced large opened pores by >15.66% and blackhead pores by >21.84%. Sebum production was decreased by 64.17%, and keratin levels by 16.47%. Additionally, skin brightness improved by 2.49%, and acne incidence was reduced by 9.59% over time on human faces.
- 02 A serum formulated with Galactomyces Ferment Filtrate, dexpanthenol, and Centella asiatica proved effective in treating post-acne hyperpigmentation (PAH) in individuals with Fitzpatrick skin types IV and V. After 8 weeks of twice-daily application, subjects showed a significantly lower melanin index and a higher L* score (indicating increased lightness).
- 03 At a 10% concentration, GFF nearly doubled the expression of antioxidative enzymes HO1 and NQO1, and increased TXNRD1 by 68% in human melanocytes. Concentrations of 2.5%, 5%, and 10% also demonstrated the ability to rescue cell viability against induced cytotoxicity.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Galactomyces/Milk Ferment Filtrate maintains stability within a pH range of 3.0–6.5 (or 4-7). It is heat-sensitive, requiring avoidance of temperatures above 40°C. Optimal storage conditions include refrigeration in a cold, dark, and dry environment. While the product may naturally shift from a yellowish to amber color over time, this does not compromise its efficacy. It is recommended for addition at the final stage of formulation, and high concentrations may necessitate the inclusion of fragrance to mask its characteristic fermented aroma.
Safety
Safety Profile
The independent Cosmetic Ingredient Review (CIR) panel tentatively affirmed Galactomyces Ferment Filtrate as safe for cosmetic use in a January 10, 2024 report, with common usage levels ranging from 10–100%. While generally well-tolerated, individuals with sensitive skin should perform a patch test, as some may experience minor allergic reactions such as redness or itching. The ingredient is considered non-comedogenic but can exacerbate fungal acne in prone individuals. It is generally regarded as safe for use during pregnancy and breastfeeding, though consulting a healthcare professional is always advised. Its EWG score of '1' indicates a very low potential for toxicity or allergies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Galactomyces/Milk Ferment Filtrate is a highly valuable and versatile ingredient, offering significant, scientifically supported benefits for hydration, barrier integrity, antioxidant defense, and the visible improvement of skin tone and texture.
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